2025年3月30日 · SLC37A4 (Solute Carrier Family 37 Member 4) is a Protein Coding gene. Diseases associated with SLC37A4 include Glycogen Storage Disease Ib and Glycogen Storage Disease Ic. Among its related pathways are Diseases …

Glucose-6-phosphate exchanger SLC37A4, also known as glucose-6-phosphate translocase, is an enzyme that in humans is encoded by the SLC37A4 gene. [5] [6] [7] It consists of three subunits, each of which are vital components of the multi-enzyme Glucose-6-Phosphatase Complex (G6Pase).

The SLC37A4 gene provides instructions for making a protein called glucose 6-phosphate translocase. This protein transports the sugar molecule glucose 6-phosphate from the fluid inside the cell (cytoplasm) to the endoplasmic reticulum, which is a structure inside cells that is involved in protein processing and transport.

2024年10月22日 · Solute carrier family 37 member 4 (SLC37A4) is known to regulate glucose-6-phosphate transport from cytoplasm to the lumen of the endoplasmic reticulum, which serves to maintain glucose...

SLC37A4, better known as the G6P transporter (G6PT), has been extensively characterized, functionally and structurally, and is the best characterized family member. G6PT contains 10 transmembrane helices with both N and C termini facing the cytoplasm.

2021年6月3日 · SLC37A4 encodes an endoplasmic reticulum (ER)-localized multitransmembrane protein required for transporting glucose-6-phosphate (Glc-6P) into the ER. Once transported into the ER, Glc-6P is subsequently hydrolyzed by tissue-specific phosphatases to glucose and inorganic phosphate during times of glucose depletion.

SLC37A4, gene responsible for glycogen storage disease type 1b, regulates gingival epithelial barrier function via JAM1 expression. Three novel SLC37A4 variants in glycogen storage disease type 1b and a literature review.

该基因调节从细胞质到内质网腔的葡萄糖-6-磷酸转运，以维持葡萄糖稳态。 它还在内质网腔中的 ATP 介导的钙螯合中发挥作用。 该基因的突变与各种形式的糖原贮积病有关。 该基因的可变剪接导致多个转录变体。 [RefSeq 提供，2009 年 8 月] This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis.

2025年2月8日 · Gene ID: 14385, updated on 8-Feb-2025. Enables glucose 6-phosphate:phosphate antiporter activity. Involved in gluconeogenesis. Acts upstream of or within several processes, including cholesterol homeostasis; glucose-6-phosphate transport; and hemopoiesis. Is active in endoplasmic reticulum membrane.

糖原累积症Ⅰb型(GSDⅠb，MIM：232220)是一种常染色体隐性遗传性糖原代谢疾病，由于SOLUTE CARRIER FAMILY 37，MEMBER 4(SLC37A4，MIM：602671)基因突变导致葡萄糖6磷酸转移酶(glucose－6－phosphate translocase，G6PT1)缺乏，一方面造成糖原在肝脏、肾脏和肠黏膜大量堆积，另一方面 ...