Sirtuins are a family of signaling proteins involved in metabolic regulation. [2][3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all …

2022年12月29日 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are …

One of the most promising targets for anti-ageing approaches are proteins belonging to the sirtuin family. Sirtuins were originally discovered as transcription repressors in yeast, however, …

2022年12月29日 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are …

Sirtuins 是一种特殊的蛋白质，需要NAD+来调节细胞健康。 它们调节控制细胞死亡的途径，它们开启和关闭抗衰老基因，修复DNA，并调节我们的新陈代谢。 在这篇文章中，你会发 …

2012年3月7日 · Sirtuins regulate protein function by NAD + -dependent post-translational modification, thereby representing a metabolic sensor. Compounds activating sirtuins could be …

2020年3月4日 · Sirtuins such as SIRT1 are conserved protein NAD (+)-dependent deacylases and thus their function is intrinsically linked to cellular metabolism. Over the past two decades, …

2018年9月14日 · Activation of sirtuins or nicotinamide adenine dinucleotide repletion induces angiogenesis, insulin sensitivity, and other health benefits in a wide range of age-related …

Sirtuin is a nicotinamide adenine dinucleotide–dependent deacetylase. One of its isoforms, Sirt1, is a key molecule in glucose, lipid, and energy metabolism. The renal protective effects of Sirt1 …

2015年11月1日 · Sirtuins are a family of evolutionary conserved proteins. Sirtuin-mediated deacetylation of critical proteins modulate mitochondrial function. Sirtuins play important …