The first sirtuin was identified in yeast (a lower eukaryote) and named sir2. In more complex mammals, there are seven known enzymes that act in cellular regulation, as sir2 does in …

2004年4月28日 · Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms …

2008年3月6日 · Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster …

In Saccharomyces cerevisceae, the protein called Sir2, has a wide range of functions including chromatin silencing, life span extension and maintenance of genomic stability. There are …

Silent information regulator 2 (Sir2) is a conserved NAD+-dependent histone deacetylase crucial for regulating cellular stress response and the aging process in Saccharomyces cerevisiae. In …

2025年1月4日 · Sir2 and Reb1 antagonistically regulate nucleosome occupancy in subtelomeric X-elements and repress TERRAs by distinct mechanisms. Spreading-dependent or …

The Sir complex represses transcription at telomeres, mating-type loci, and ribosomal DNA. Unlike SIR3 and SIR4, the SIR2 gene is highly conserved in organisms ranging from archaea …

2005年10月1日 · The importance of NAD +-dependent deacetylases (Sir2 family or sirtuins) in cell survival, ageing and apoptosis has ignited a flurry of both chemical and cellular investigations …

Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is predominantly found in the …

本论文还对SIR2-HerA系统抗噬菌体活性等重要免疫机制进行了表征，证明其具有显著的抗λ噬菌体能力，并对其抗噬菌体原理进行了推测与解析。 总体来说,本论文对SIR2-HerA系统的多重功 …