Siglec - Wikipedia
Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type …
SIGLEC1 Gene - GeneCards | SN Protein | SN Antibody
2025年3月30日 · SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1) is a Protein Coding gene. Diseases associated with SIGLEC1 include Heart Block, Congenital and Rheumatoid Arthritis. …
唾液酸结合免疫球蛋白样凝集素 1 (siglec-1) 在免疫学和传染病中 …
Siglec-1，也称为 Sialoadhesin (Sn) 和 CD169，在脊椎动物中高度保守，Siglec-1 具有 17 个免疫球蛋白样结构域，是 Siglec 家族中最大的成员。 Siglec-1 的表达主要存在于树突细胞 (DC)、 …
Siglec-1 expression on monocytes is associated with the …
2022年5月5日 · Siglec-1 on monocytes is a novel IFN-inducible biomarker in JDM that correlates with clinical disease activity and identifies patients at risk for a suboptimal treatment response. …
Siglecs，自免病与癌症治疗的新希望 - 知乎
急性肾损伤模型研究发现Siglec-1阳性巨噬细胞参与募集中性粒细胞；可溶性Siglec-5可以结合P-选择素糖蛋白配体1 (PSGL1)，从而促进白细胞滚动和加剧炎症反应；Siglec-7与P-选择素在活 …
【Siglec免疫检查点】——布局免疫治疗下一个十年 - 知乎
2023年9月19日 · Siglecs（唾液酸 结合免疫球蛋白样凝集素，Sialic acid-binding immunoglobulin-like lectin）是一类属于I型凝集素家族的免疫调节性唾液酸结合 受体蛋白，能与含有唾液 …
退！退！退！肿瘤治疗潜在靶点-Siglec家族蛋白 - 知乎
Siglec家族包括三个主要的功能：1:Siglec可能被含有唾液酸的病原体劫持导致感染或逃避免疫防御；2：作为免疫细胞相互作用和功能受体，如Siglec-1或CD169用于巨噬细胞将抗原呈递给T细 …
Siglecs and their roles in the immune system - Nature
Siglecs are sialic-acid-binding immunoglobulin-like lectins that are mostly expressed by cells of the immune system. Siglecs can be divided into two subsets based on their sequence …
SIGLEC1 (CD169): a marker of active neuroinflammation in the
2021年5月13日 · SIGLEC1 (Sialic acid-binding immunoglobulin-type lectins-1, CD169) is a sialic acid binding cell-surface protein, exclusively expressed on monocytes and...
The role of sialic acid-binding immunoglobulin-like-lectin-1 (siglec-1 …
Siglec-1 mediates dissemination of HIV-1 in activated tissues enhancing viral spread via infection of DC/T-cell synapses. Overall, the ability of Siglec-1 to bind a variety of target cells within the …