Senescence of endplate osteoclasts induces sensory innervation …
2024年6月19日 · To investigate spinal hypersensitivity, pain behavioral tests, including the von Frey test, hot plate test, and active wheel test, were conducted in sham, LSI, and aged mice …
Parathyroid hormone treatment partially reverses endplate …
Immunofluorescence analysis showed that Dil-positive and PGP9.5-positive neurons were highly abundant in the DRGs of LSI and aged-mice injected with vehicle relative to sham, and PTH …
Nature Communications | 自供电摩擦电响应微针可控释放囊泡， …
2024年7月11日 · 临床正常和退化 NP 组织样本的 RNA 测序 (RNA-seq)示意图工作流程以及 LSI-E 组和 LSI 组之间以及退化和正常 NP 样本（ n = 3 个生物学独立样本）之间重叠 DEG 的相关 …
Sensory innervation in porous endplates by Netrin-1 from ... - Nature
2019年12月10日 · Here we report that in mice, osteoclasts induce sensory innervation in the porous endplates which contributes to spinal hypersensitivity in mice. Sensory innervation of …
sham mice. By three-dimensional microcomputed tomography (μCT) analysis, we found a significant increase in the porosity and separation of trabecular bone (Tb.Sp) within the …
Alleviation of inflammation in paraventricular nucleus and …
2025年3月6日 · We hypothesized that lumbar spine instability (LSI) surgery in mice elevated sympathetic outflow by activating TLR4/NF-κB axis in PVN, and exacerbated endplate …
Inhibition of aberrant Hif1α activation delays intervertebral disc ...
2022年1月5日 · Immunostaining analysis showed that the number of cells positive for HIF1α gradually increased in degenerative EP cartilage at 2 and 4 weeks after LSI surgery compared …
A greater number of SnOCs are associated with endplate
Here, we report that greater numbers of senescent osteoclasts (SnOCs) are observed in mouse models of spinal hypersensitivity, like lumbar spin... ... such as the von Frey test, hot plate test …
线粒体蛋白Sirtuin5 去琥珀酰化修饰调节线粒体稳态介导压缩诱导 …
2024年10月9日 · 琥珀酰化（Succinylation）是最近发现的蛋白质翻译后修饰，涉及可逆的蛋白质修饰过程，通常发生在赖氨酸残基上，琥珀酰辅酶A（succinyl-CoA）是赖氨酸琥珀酰化的辅 …
Senescence of endplate osteoclasts induces sensory innervation …
2023年11月14日 · Depletion of SnOCs reduces spinal degeneration and sustains endplate microarchitecture in LSI mice. (a) μCT images of adult sham mice and 3-month-old LSI model …