Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene. [5][6][7] PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases.

2025年3月30日 · SERPINB9 (Serpin Family B Member 9) is a Protein Coding gene. Diseases associated with SERPINB9 include Pituitary Adenoma 2, Growth Hormone-Secreting and Patella, Chondromalacia Of. Among its related pathways are Nuclear receptors meta-pathway and Glucocorticoid receptor pathway.

SERPINB9 (Sb9), also known as Proteinase Inhibitor 9 (PI-9), is a well-known endogenous inhibitor of Granzyme B (GzmB). GzmB is a potent cytotoxic molecule secreted by cytotoxic T lymphocytes and natural killer cells, which plays a crucial role in inducing apoptosis in target cells during immune responses.

Serine proteinase inhibitor B9 (serpin B9) is a member of the serine protease inhibitor superfamily, which is widely found in animals, plants and microorganisms. Serpin B9 has been reported to protect cells from the immune‑killing effect of granzyme B …

Serpin B9 controls tumor cell killing by CAR T cells. SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response. Decreased GZMB, NRP1, ITPR1, and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients.

In NSCLC we commonly observed rare SERPINB9-positive cancer cells, possibly accounting for reservoirs of ICB-resistant cells. While underscoring SERPINB9 as a potential target to combat immunotherapy resistance, these results suggest its potential to serve as a prognostic and predictive biomarker.

Serpinb9 (Sb9, also called Spi6) is an intracellular inhibitor of granzyme B (grB) that protects cytotoxic lymphocytes from grB-mediated death. In addition, Sb9 is also expressed in accessory immune cells, including dendritic cells (DCs), although its role is debated.

2024年10月28日 · Gene target information for SERPINB9 - serpin family B member 9 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

SerpinB9 is important for tumor cell survival and for the presence of immunosuppressive cells in the tumor microenvironment, and a small-molecule inhibitor of SerpinB9 can reduce tumor growth and increase tumor immunogenicity in several mouse models of cancer.

Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including T cell mediated cytotoxicity; acute inflammatory response to antigenic stimulus; and negative regulation of T cell apoptotic process. Located in cytoplasm.