A serine/threonine protein kinase (EC 2.7.11.-) is a kinase enzyme, in particular a protein kinase, that phosphorylates the OH group of the amino-acid residues serine or threonine, which have similar side chains. At least 350 of the 500+ human protein kinases are …

Ser/Thr 蛋白磷酸酶依据抑制因子的影响和催化 底物特异性的不同, 又可以具体分为PP1 和PP2 两类, PP1能被热稳定的蛋白抑制剂I-1 和I-2 所抑制, 特异

2018年7月6日 · Mechanistically, STL involves imine capture, 5-endo-trig ring–chain tautomerization, O-to-N [1,5] acyl transfer to afford the N,O-benzylidene acetal-linked peptide, and acidolysis to regenerate the Xaa–Ser/Thr linkage (where Xaa is the amino acid) at the ligation site. The high abundance of serine and threonine residues (12.7%) in naturally ...

2024年10月1日 · Serine and threonine can enhance the growth ability of Lactobacillus bulgaricus sp1.1 under salt stress by increasing the expression of Ser/Thr kinase. Ser/Thr kinase, as a key protein in bacterial division, can phosphorylate the division proteins FtsZ and DivIVA and transmit cell wall synthesis information to DivIVA to participate in the cell ...

Recent biochemical and structural investigation of protein Ser/Thr phosphatases has given considerable insight into the mechanisms that underlie their assembly, activation, catalysis, substrate recognition, and regulation.

2024年6月20日 · Pseudomonas aeruginosa is one of the leading causes of nosocomial infections worldwide and has emerged as a serious public health threat, due in large part to its multiple virulence factors and remarkable resistance capabilities. Stk1, a eukaryotic-type Ser/Thr protein kinase, has been shown …

Ser/Thr phosphorylation is the major mechanism of regulatory phosphorylation in eukaryotes. This mechanism was long considered the exclusive province of eukaryotes, despite that in 1969, one year after the initial observation of Ser/Thr kinases in eukaryotic cells, a cAMP-dependent Ser/Thr kinase was described in Escherichia coli .

Phosphorylation on specific amino acid residues, most commonly serine (Ser), threonine (Thr), tyrosine (Tyr), histidine (His), and aspartate (Asp), can control the activity of target proteins, either directly, for example, by inducing conformational changes in the active site, or indirectly, by regulating protein-protein interactions.

Ser/Thr Kinase is an enzyme in the eukaryotic protein kinase (ePK) superfamily that recognizes the hydroxyl group of serine or threonine residues for phosphorylation. Ser/Thr Kinase is divided into phosphorylation receptor molecule kinase and intracellular signal transduction protein kinase, which affects growth, differentiation, cell cycle ...

2020年4月26日 · Serine, threonine, and tyrosine (Ser/Thr/Tyr) phosphorylation plays wide-ranging roles in bacterial pathogens affecting both basic physiology and pathogen-specific processes. Recent advances in bacterial phosphoproteomics have significantly increased our insight into the width of pathogen Ser/Thr/Tyr phosphorylation substrates.