Mar 30, 2025 · SEMA3A (Semaphorin 3A) is a Protein Coding gene. Diseases associated with SEMA3A include Hypogonadotropic Hypogonadism 16 With Or Without Anosmia and Brugada Syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

Apr 12, 2024 · Here we demonstrate that Neuropilin-1 (NRP1) and Plexin-A1 and Plexin-A4 are upregulated on stimulated CD8 + T cells, allowing tumour-derived SEMA3A to inhibit T cell migration and assembly of...

May 5, 2013 · Sema3A, a member of the semaphorin family of proteins, is shown to regulate bone remodelling indirectly by modulating sensory nerve development in mice.

Semaphorin 3A (Sema3A) is a neuroinformatic protein molecule with widespread expression across various tissues and organs. Recent investigations have unveiled its pivotal role in the skeletal system, primarily through its binding interactions with ...

Semaphorin 3A is a glycoprotein secreted by multiple human cell types. From immunological point of view, this is a rather unusual factor exerting simultaneously neuronal and immunoregulatory properties, and additionally acting as an anti-angiogenic agent.

Mar 5, 2024 · Semaphorin 3A protects against alveolar bone loss during orthodontic tooth movement in mice with periodontitis.

Semaphorin 3A (Sema3A) is a protein identified originally as a diffusible axonal chemorepellent. Sema3A has multifunctional roles in embryonic development, immune regulation, vascularization, and oncogenesis.

Feb 8, 2025 · Demonstrate SEMA3A as a naturally occurring protein that selectively inhibits Kv4.3 and SEMA3A as a possible Brugada syndrome susceptibility gene through a Kv4.3 gain-of-function mechanism. SEMA3a enhanced CD72 expression in B cells of …

Mar 22, 2019 · Semaphorin 3A (sema3A) belongs to the sub-family of the immune semaphorins that function as regulators of immune-mediated inflammation. Sema3A is a membrane associated molecule on T regulatory cells and on B regulatory cells.

Feb 8, 2025 · Sema3a regulates endothelial cell number and podocyte differentiation during glomerular development. Sema3A is an endogenous and effective antiangiogenic agent that stably normalizes the tumor vasculature; Sema3A may facilitate the initial growth of CA1 apical dendrites via the activation of p35 protein/cyclin-dependent kinase 5