Sekun Park. Other names Saegeun Park, Sae-Geun Park. Research specialist, HHMI. Verified email at uw.edu. Neuroscience. Articles Cited by Public access. Title. Sort. Sort by citations Sort by year Sort by title. Cited by. ... SG Park, YC Jeong, DG Kim, MH Lee, A …

A neuroscientist with 14+ years of experience dissecting neural circuits. Playing a role in research, team lead and mentoring. Skilled in stereotaxic brain surgery, viral gene delivery, and opto/chemogenetic manipulation to probe specific neuronal populations. Pioneered in vivo Ca2+ imaging techniques (fiber photometry and 1p miniscope) and single-cell RNA sequencing. Studied in fields of pain ...

2024年9月5日 · Here, we report the development of two genetically encoded tools for investigating peptidergic transmission in behaving mice: a genetically encoded large dense core vesicle (LDCV) sensor that detects presynaptic neuropeptide release and a genetically encoded silencer that specifically degrades neuropeptides inside LDCVs.

Sekun Park's 8 research works with 34 citations and 252 reads, including: Novel genetically encoded tools for imaging or silencing neuropeptide release from presynaptic terminals in vivo

2024年3月25日 · To explore this possibility, we established an aversive SOC behavioral paradigm in mice and monitored Calca neuron activity via single-cell calcium imaging during SOC and subsequent recall phases. These neurons were activated not only by CS1 following its association with the US but also by CS2 after SOC.

2023年1月19日 · Here, we report the development of two genetically encoded tools for investigating peptidergic transmission in behaving mice: a genetically encoded large dense core vesicle (LDCV) sensor that detects the neuropeptides release presynaptically, and a genetically encoded silencer that specifically degrades neuropeptides inside the LDCV.

2024年4月23日 · The parabrachial nucleus (PBN) is a hub that relays aversive sensory information and appears to play a role in nociplasticity. Here, by preventing PBN Calca neurons from releasing neurotransmitters, we demonstrate that activation of Calca neurons is necessary for the manifestation and maintenance of chronic pain.

2020年8月28日 · Parabrachial CGRP neurons receive diverse threat-related signals and contribute to multiple phases of adaptive threat responses in mice, with their inactivation attenuating both unconditioned behavioral responses to somatic pain and fear-memory formation.

2024年4月7日 · Logan F. Condon, Ying Yu, Sekun Park, FengCao,JordanL.Pauli,TylerS.Nelson, Richard D. Palmiter Correspondence [email protected] In brief Condon et al. demonstrate that activity within parabrachial Calca neurons is both necessary for the manifestation of chronicneuropathicpainandsufficientto induce nociplasticity. Chronic activation