iScience丨线粒体琥珀酸脱氢酶复合物控制着炎症巨噬细胞中的 …
2023年9月23日 · SDH/CII 需要四个亚基特异性伴侣介导 SDHA、SDHB 和 SDHC + SDHD 的独立成熟，才能发挥正常的酶活性。 首先，作者通过辅酶Q10类似物十烷基泛醌测定琥珀酸到人工 …
The SDH mutation database: an online resource for succinate ...
2005年11月16日 · The SDHA, SDHB, SDHC and SDHD genes encode the subunits of succinate dehydrogenase (succinate: ubiquinone oxidoreductase), a component of both the Krebs cycle …
SDHA Germline Mutations in SDH-Deficient GISTs: A Current …
2023年3月4日 · Wild type GIST driven by germline mutations in SDHB, SDHC, or SDHD subunits is a component of the Carney-Stratakis syndrome, an inherited predisposition syndrome …
SDHD Gene - GeneCards | DHSD Protein | DHSD Antibody
2025年3月30日 · SDHD (Succinate Dehydrogenase Complex Subunit D) is a Protein Coding gene. Diseases associated with SDHD include Pheochromocytoma/Paraganglioma Syndrome …
琥珀酸脱氢酶复合亚基 D（SDHD）基因 | MCE
关于 sdhd Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:112,086,873-112,095,794 (from NCBI) This gene has 9 transcripts (splice variants), 229 orthologues and is …
SDH MUTATIONS IN TUMOURIGENESIS AND INHERITED …
In this review we summarize the most recent knowledge about the role of SDH in tumorigenesis, including spectrum and prevalence of mutations, related phenotypes, and the biological …
The Role of Immunohistochemistry and Molecular Analysis of …
2018年11月12日 · In patients with germline SDHD or SDHAF2 mutations, tumors develop almost exclusively if mutations are inherited via the paternal line. Both genes are located on the long …
如果您有 SDHD 基因突变, 这意味着您会患有遗传性副神经节瘤-嗜铬细胞瘤 (PGL/PCC)综合征。 SDHD 基因突变会增加罹患某些类型肿瘤的⻛ 险, 包括副神经节瘤和嗜铬细胞瘤,通常为影响神 …
International consensus on initial screening and follow-up of ...
Mutations in the SDHx genes (SDHA, SDHB, SDHC and SDHD), which encode the four subunits of the mitochondrial enzyme succinate dehydrogenase (SDH), are associated with a …
从肾细胞癌入手学习遗传学综合征-遗传性SDH缺陷型肾细胞癌（三）
2024年4月29日 · SDHB免疫组化已成为检测SDH缺陷、线粒体复合体II功能缺陷所致肿瘤的明确措施。 免疫组化检测SDHB和SDHA，是临床实践中进行综合征相关遗传学检测的分流措施。 对 …