The succinate dehydrogenase (also called SDH or Complex II) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). SDHB is one of four protein subunits forming succinate dehydrogenase, …

2021年6月18日 · Stains & molecular markers - SDHB (succinate dehydrogenase); mitochondrial enzyme complex involved in the Krebs (or tricarboxylic acid) cycle and the electron transport chain, essential for normal aerobic respiration

2023年9月23日 · Sdha 和 Sdhb 是巨噬细胞效应功能的关键角色 有报道称，药理抑制 SDHA 可降低 LPS 诱导的 IL-1β mRNA 和蛋白表达，但不会改变其他促炎细胞因子（包括 IL-6 和 TNF-α）的分泌。

2008年5月21日 · SDHA, SDHB, SDHC, and SDHD are four nuclear genes responsible for hereditary PGL/PCC syndromes. They encode the four subunits of the mitochondrial enzyme succinate dehydrogenase (SDH).

这种肿瘤抑制基因编码琥珀酸脱氢酶 (SDH) 酶复合物的铁硫蛋白亚基，该酶复合物在线粒体中起着关键作用。 SDH 酶复合物由四个核编码亚基组成。

2023年11月1日 · This paper reviews the relationship between SDHB mutations and related cancers, discusses the molecular mechanism of SDHB mutations that may lead to tumor formation, analyzes the mutation spectrum, structural domains, and penetrance of SDHB and sorts out some of the previously discovered diseases.

2025年3月30日 · This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits.

Succinate dehydrogenase (SDH) is a key mitochondrial enzyme complex composed of 4 subunits. SDH histochemistry is routinely utilized in the assessment of muscle biopsies to reveal underlying pathology such as subsarcolemmal mitochondrial aggregates.

2023年10月1日 · Succinate dehydrogenase (SDH) connects oxidative phosphorylation and TCA cycle. Four major assembly factors that facilitate the assembly and maturation of the SDH complex. SDHA is the most commonly identified pathogenic variant in SDH deficiency. Mutations related to SDH deficiency induce the loss of tumor suppressor function.

2019年5月29日 · 概述： 琥珀酸脱氢酶（SDH）复合体是由SDHA、SDHB、SDHC和SDHD四个亚单位组成的关键呼吸酶。 当SDH的任何成分出现双等位失活时，SDHB免疫组化染色都是阴性，这在没有综合征疾病的情况下是非常罕见的。