The authors concluded that biannual rapid-sequence noncontrast MRI is effective to monitor individuals with SDHx mutations. We recently published our SDHB cohort data [25], which …

2025年3月6日 · SDH mutations are common in head and neck paragangliomas, except for SDHB, which is associated with sympathetic paragangliomas. SDHB also confers a higher risk of …

2021年5月21日 · Mutations in the SDHx genes (SDHA, SDHB, SDHC and SDHD), which encode the four subunits of the mitochondrial enzyme succinate dehydrogenase (SDH), are …

MRI detected all SDHB -related tumours except for two mediastinal PGLs. One patient (patient 3) was found to have a PCC on MRI, with a synchronous mediastinal PGL which was later …

Whole-body MRI had a higher sensitivity for SDH-related tumors than biochemical testing in patients undergoing screening due to their SDHB or SDHC mutation status. Whole-body MRI …

2019年9月9日 · Most commonly, up to 25% of all PC-PGLs are associated with mutations in one of the succinate dehydrogenase (SDH) enzyme subunit genes. The resulting familial PC-PGL …

Clinical and imaging data of 47 patients with SDHx mutations (SDHB (36), SDHC (6) and SDHD (5)) who had surveillance for detection of paragangliomas by rapid-sequence non-contrast …

2022年2月16日 · Surveillance screening for asymptomatic relatives consisted of annual plasma metanephrine measurement and whole-body MRI with contrast at 3-5 yearly intervals. Results: …

An initial tumour screening should be performed after the discovery of an SDHA, SDHB, SDHC or SDHD-pi mutation relying on blood pressure measurements, a symptoms or signs …

2013年8月11日 · Whole-body MRI had a higher sensitivity for SDH-related tumors than biochemical testing in patients undergoing screening due to their SDHB or SDHC mutation …