2021年6月18日 · Succinate dehydrogenase (SDH) is a mitochondrial enzyme complex involved in the Krebs (or tricarboxylic acid) cycle and the electron transport chain, essential for normal …

Screen for potential SDH germline mutations in patients with certain tumor types.

Previously, we have shown that SDHB immunohistochemistry is a reliable technique for the identification of pheochromocytomas and paragangliomas caused by SDHx mutations. We …

Aids in the identification of succinate dehydrogenase B-deficient tumors. For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID …

Succinate dehydrogenase (SDH) is a key mitochondrial enzyme complex composed of 4 subunits. SDH histochemistry is routinely utilized in the assessment of muscle biopsies to reveal …

2015年2月27日 · We conclude that SDHB/SDHA immunohistochemistry is a reliable tool to identify patients with SDH-x mutations with an additional value in the assessment of genetic …

Remarkably, immunohistochemistry (IHC) for SDHB becomes negative if any component of the SDH complex is lost due to mutations of SDHx genes . Therefore, efforts to validate IHC for …

2022年5月11日 · Immunohistochemistry (IHC) for the succinate dehydrogenase B (SDHB) subunit can help to detect SDH-deficiency, which manifests as complete loss of staining in tumour cells.

In this study, we evaluated the utility of succinate dehydrogenase B (SDHB) immunohistochemistry (IHC) in 27 muscle biopsies, including 13 mitochondrial myopathies …

Immunohistochemistry (IHC) for the succinate dehydrogenase B (SDHB) subunit can help to detect SDH-deficiency, which manifests as complete loss of staining in tumour cells.