2015年11月18日 · Stromal cell-derived factor 1 (SDF-1) is a chemokine that can be expressed in injured cardiomyocytes after myocardial infarction (MI). By combining with its receptor CXCR4, SDF-1 induced stem...

CXCR4作为具有代表性的G蛋白耦联受体（GPCR）一员，在介导肿瘤定向迁移、侵袭和转移中发挥着重要的作用，多项CXCR4开发药物在临床治疗中表现出巨大的潜力，这些药物将为肿瘤免疫治疗开辟一条新的途径。 什么是CXCR4？ 趋化因子受体（C X C chemokine receptor 4，CXCR4）是一个具有7次跨膜结构的 G蛋白耦联受体 （G Protein-Coupled Receptor，GPCR），由352个氨基酸组成，其编码基因位于染色体2q21 [1-2]。 CXCR4作 …

2022年1月24日 · SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its receptors [CXC chemokine receptor 4 (CXCR4)] form a signaling pathway that plays critical roles in different pathological and physiological mechanisms, including embryogenesis, wound healing, angiogenesis, tumor growth, and proliferation.

Recent evidence demonstrates that the chemokine stromal-cell derived factor-1 (SDF-1, also known as CXCL12) has a major role in the recruitment and retention of CXCR4 + BM cells to the neo-angiogenic niches supporting revascularization of ischemic tissue and tumor growth.

2005年9月18日 · Here we describe a unique function for the chemokine receptor CXCR4 expressed on bone marrow endothelial cells, which efficiently internalize circulating SDF-1, resulting in its translocation...

基质细胞衍生因子-1 (Stromal cellderived factor-1,SDF-1)是新近发现的一种细胞因子,属CXC (Cys-X-Cys)类趋化蛋白,系统命名CXCL12 (CXC chemokine ligand-12),是已知唯一能与受体CXCR4结合并激活的天然趋化因子.SDF-1和CXCR4广泛地表达于多种细胞和组织中,包括免疫细胞、脑、心脏 …

在血细胞生成过程中“导 航”白细胞至淋巴样器官、骨 髓及胸腺。 CXCL12(基 质细胞衍生因子 1,SDF 1)是自稳型CXC类 趋化因子,在 许多组. 织器. 脏、骨 骼肌、脑 、肾 、心 脏、皮 肤和骨髓等。CXCL. 2 于海涛 阎辉 功能性CXCR4的 细胞,会 沿着CXCL12浓度梯度迁移/侵 入。 表达CXCR4的促血管生成细胞包括成熟和不成熟的造血细胞、�....

Recent evidence demonstrates that the chemokine stromal-cell derived factor-1 (SDF-1, also known as CXCL12) has a major role in the recruitment and retention of CXCR4 (+) BM cells to the neo-angiogenic niches supporting revascularization of ischemic tissue and tumor growth.

2015年11月18日 · Stromal cell-derived factor 1 (SDF-1) is a chemokine that can be expressed in injured cardiomyocytes after myocardial infarction (MI). By combining with its receptor CXCR4, SDF-1 induced stem and progenitor cells migration. CXCR7, a novel receptor for SDF-1, has been identified recently. We aimed to …

2022年2月23日 · Blocking the SDF-1/CXCR4 axis with AMD3100 significantly reduced the number of hAD-MSCs homing to ovaries with POI and further reduced their efficacy in POI treatment. The binding of SDF-1 to CXCR4 activated the PI3K/Akt signalling pathway, and LY294002 significantly inhibited hAD-MSC migration induced by SDF-1 in vitro.