ZDHHC3-mediated SCAP S-acylation promotes cholesterol
2024年11月26日 · Here, we show that the palmitoyltransferase ZDHHC3 and depalmitoylase ABHD17A regulate HCC cell cholesterol biosynthesis by dynamically S-acylating SREBP …
Cholesterol sensor SCAP contributes to sorafenib resistance by ...
2022年3月30日 · SCAP is overexpressed in HCC tissues and hepatocellular carcinoma cell lines with sorafenib resistance, while SCAP inhibition could improve sorafenib sensitivity in …
Here, we show that the palmitoyltransfer-ase ZDHHC3 and depalmitoylase ABHD17A regulate HCC cell cholesterol biosynthesis by dynamically S-acylating SREBP cleavage-activating …
<br>ZDHHC3 介导的 SCAP S-酰化促进肝细胞癌胆固醇生物合成和 …
We identified a small-molecule inhibitor of ZDHHC3 that, combined with anti-PD-1 immunotherapy, inhibited diethyl nitrosamine (DEN)/CCl 4 -induced HCC growth in mice. …
胆固醇传感器 SCAP 通过调节肝细胞癌中的自噬导致索拉非尼耐 …
2022年3月30日 · SCAP 在 HCC 组织和索拉非尼耐药的肝细胞癌细胞系中过表达，而 SCAP 抑制可以提高索拉非尼耐药 HCC 细胞对索拉非尼的敏感性。 此外，我们发现 SCAP 介导的索拉 …
Cholesterol attenuated the progression of DEN-induced …
2019年2月19日 · In the present study, we provided compelling evidence that cholesterol inhibited HCC progression via inhibiting SCAP/SREBP mediated fatty acid de novo synthesis, which …
胆固醇通过抑制SCAP介导的脂肪酸从头合成来减弱DEN诱导的肝 …
胆固醇负载的SK hep1细胞中SCAP的过表达促进了SREBP1的核易位以及FAS和ACC-1的表达，从而促进了SK hep1细胞的增殖，迁移和侵袭。 SCAP的抑制还抑制了SK hep1细胞中胆固醇缺 …
METTL3 drives NAFLD-related hepatocellular carcinoma and is a ...
2023年8月8日 · We deciphered the mechanism of action of METTL3, involving m 6 A-modification of SREBP cleavage-activating protein (SCAP), which promotes cholesterol biosynthesis, …
ZDHHC3-mediated SCAP S-acylation promotes cholesterol
2024年11月26日 · Here, we show that the palmitoyltransferase ZDHHC3 and depalmitoylase ABHD17A regulate HCC cell cholesterol biosynthesis by dynamically S-acylating SREBP …
Dr. Ed Prochownik published in Cell Reports
2024年12月5日 · Here, we show that the palmitoyltransferase ZDHHC3 and depalmitoylase ABHD17A regulate HCC cell cholesterol biosynthesis by dynamically S-acylating SREBP …