2016年1月13日 · We demonstrate that upon IL-4R engagement by its ligand, activation of the JAK3-STAT6 pathway leads to the acquisition of DC-specific demethylation and expression …

2019年6月3日 · Polarized secretion concentrated IL4 at the IS, which promoted the activation of signal transducer and activator of transcription 6 (STAT6) and production of IL12 in DCs and …

2021年8月28日 · Thus, we conclude that the STAT6 signaling pathway modulates the immune response after antigen targeting to cDC2s via the DCIR2 receptor: while STAT6 stimulates the …

2021年11月18日 · We show that differentiation of CD11blo migratory DC2s—a DC2 population unique to the dermis—required IL-13 signaling dependent on the transcription factors STAT6 …

2018年11月14日 · Here we show that intranasal administration of STAT6-IP at the time of antigen priming with ovalbumin (OVA), in conjunction with the Nod2 agonist, MDP, reduced …

Purpose:: We had previously shown that STAT pathways are differentially activated as dendritic cells (DC) differentiate from precursor (pDC) to immature (iDC) and finally to mature DC …

此外，IL-4 信号通过 PPARγ 和 PPARγ 靶基因（包括FABP4） 启动子上的信号转导和转录激活因子 6 (STAT6) 之间的相互作用增强 PPARγ 活性. 因此，STAT6 通过促进 DNA 结合并因此增 …

1998年7月1日 · To directly assess the role of STAT6 in IL-4R- and CD40-mediated germline transcription and switching, we have analyzed these events in splenic B cells from STAT6 …

Here, we show that signal transducer and activator of transcription 1 (STAT1) deficiency in macrophages enhanced cell-cell fusion and elevated DC-STAMP expression in FBGCs. By …

•STAT6 degradation can achieve dupilumab–like pathway inhibition. We developed highly potent and selective oral STAT6 degraders and assessed their functions in disease-relevant human …