STAT1 - Wikipedia
Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.
STAT1 Gene - GeneCards | STAT1 Protein | STAT1 Antibody
Mar 30, 2025 · Complete information for STAT1 gene (Protein Coding), Signal Transducer And Activator Of Transcription 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
STAT1 and Its Crucial Role in the Control of Viral Infections
The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the immune response against viruses and other pathogens by transducing, in the nucleus, the signal from type I, type II and type III IFNs. STAT1 activates the ...
STAT1 gene: MedlinePlus Genetics
The STAT1 gene provides instructions for making a protein that is involved in multiple immune system functions, including the body's defense against a fungus called Candida. When the immune system recognizes Candida, it generates cells called Th17 cells.
Clinical Relevance of Gain- and Loss-of-Function Germline …
Background: Germline mutations in signal transducer and activator of transcription 1 (STAT1), which lead to primary immunodeficiency, are classified as defects in intrinsic and innate immunity.
STAT1 and Its Crucial Role in the Control of Viral Infections
Apr 7, 2022 · STAT1 plays a key role in the immunoglobulin class-switch recombination through the upregulation of T-bet; it also plays a key role in the production of T-bet+ memory B cells that contribute to tissue-resident humoral memory by mounting an IgG response during re-infection.
STAT1 signal transducer and activator of transcription 1 [Homo …
Mar 16, 2025 · Gene target information for STAT1 - signal transducer and activator of transcription 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
Transcriptional regulation by STAT1 and STAT2 in the interferon …
STAT1 and STAT2 proteins are key mediators of type I and type III interferon (IFN) signaling, and are essential components of the cellular antiviral response and adaptive immunity. They associate with IFN regulatory factor 9 (IRF9) to form a ...
Complex roles of Stat1 in regulating gene expression
May 25, 2000 · Stat1 is a fascinating and complex protein with multiple, yet contrasting transcriptional functions. Upon activation, it drives the expression of many genes but also suppresses the transcription...
STAT1 gain-of-function heterozygous cell models reveal diverse ...
May 14, 2021 · We generated heterozygous mutants in diploid HAP1 cells using CRISPR/Cas9 base-editing, targeting the endogenous STAT1 gene.