We integrate spectroscopic optical coherence tomography (SOCT) with stimulated Raman scattering (SRS) to enable simultaneously multiplexed spatial and spectral imaging with sensitivity to many endogenous biochemical species that play an important role in biology and medicine.

2023年10月27日 · Stimulated Raman scattering (SRS) microscopy has shown enormous potential in revealing molecular structures, dynamics, and couplings in complex systems. However, the sensitivity of SRS is fundamentally limited to the millimolar level due to shot noise and the small modulation depth.

2024年8月6日 · Inspired by physics-informed neural networks, we propose SRS-Net, which combines the efficient automatic differentiation and powerful representation ability of neural networks with the...

2017年4月19日 · The method, termed SRS-SOCT, has the potential to achieve fast, volumetric, and highly sensitive label-free molecular imaging, which would be valuable for many applications. We demonstrate the approach by imaging excised human adipose tissue and detecting the lipids’ Raman signatures in the high-wavenumber region.

2023年4月26日 · 相较于频域OCT，SS-OCT和SS-OCTA的扫描波长更长，有助于更清晰地显示色素组织下方的结构和血管系统；SS-OCT和SS-OCTA的扫描速度更快，能一次性获得更大的范围的图像，更高的空间分辨率，甚至可以对眼前节进行360度的显示。

2021年8月17日 · Swept-source optical coherence tomography (SS-OCT) is an imaging tool capable of providing three-dimensional information of biological tissues in vivo...

2024年2月18日 · 光学相干断层扫描（OCT: optical coherence tomography）是一种非侵入式光学成像技术，可提供实时、1维深度、2维截面或3维立体图像，分辨率可达微米量级（um），成像深度为毫米量级（mm）。 如图1所示，如果以分辨率和成像深度两个方面来讨论，OCT成像技术填补了共焦显微镜和超声技术之间的空白。 OCT基于光学相干原理，以近红外光为光源，迈克尔逊干涉仪为核心光学结构，产生光学干涉信号实现成像。 图2介绍了迈克尔逊干涉仪的基本结构。 …

Swept-source OCT (SS-OCT; DRI-OCT, Topcon Japan) is the latest milestone in retinal and choroidal imaging. To overcome scattering by the RPE, which disabled visualization of deeper lying structures, a longer wavelength was adopted for this machine (1050 nm vs 840 nm in SD-OCT), and photodetectors instead of CCD cameras led to a further increase ...

2023年5月1日 · The fast development of swept-source optical coherence tomography (SS-OCT) and swept-source optical coherence tomography angiography (SS-OCTA) enables both anterior and posterior imaging of the eye. These techniques have evolved from a research tool to an essential clinical imaging modality.

2022年11月29日 · 本文深入探讨了扫频光学相干层析（SS-OCT）的工作原理，包括扫频光源、干涉过程、平衡探测器的作用以及信号处理。 通过傅里叶变换，SS-OCT能够实现样品深度信息的快速获取。