Sterol-regulatory element binding proteins (SREBPs)胆固醇调节元件结合蛋白(SREBP)是位于内质网的细胞内胆固醇敏感器，通过Insig-Srebp-Scap途径对细胞内胆固醇进行反馈调节。

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene. [5]

Sterol regulatory element-binding proteins (SREBPs, including SREBP1a, SREBP1c, and SREBP2) are basic-helix-loop-helix leucine zipper (bHLH-Zip) transcription factors that regulate the synthesis and cellular uptake of two major building blocks of …

SREBP有三个结构域：N-端细胞浆结构域，包含a basic helix-loop helix (bHLH) DNA-binding motif，当其从SREBP解离后入核，发挥转录因子的作用；中心膜锚定结构域，包含2次跨膜α螺旋；C-端细胞浆调控结构域。

2021年1月15日 · 哺乳动物中，srebp有三种不同的形式，分别是srebp-1a, srebp-1c和srebp-2。 SREBP-1系列主要负责脂肪的从头合成，a和c在不同的组织中的表达谱不一样；SREBP-2主要负责胆固醇的代谢和稳态 【1,2】 。

Sterol-regulatory element-binding protein (SREBP)-2 is a key regulator of cholesterol. When cells are deprived of cholesterol, proteolytic cleavage releases the NH(2)-terminal domain of SREBP-2 that binds and activates the promoters of SREBP-2 …

2017年8月29日 · In the presence of cholesterol and oxycholesterols (25-hydroxycholesterol and 27-hydroxycholesterol), the sterol regulatory element-binding protein 2 (SREBP2)–SREBP cleavage-activating...

2002年9月1日 · Sterol-regulatory element-binding protein (SREBP)-2 is a key regulator of cholesterol. When cells are deprived of cholesterol, proteolytic cleavage releases the NH 2 -terminal domain of SREBP-2 that binds and activates the promoters of SREBP-2-regulated genes including the genes encoding the low-density lipoprotein (LDL) receptor, 3 ...

2024年7月9日 · SPRING activates S1P by dislodging its inhibitory pro-domain and stabilizing intra-domain contacts. Functionally, SPRING licenses S1P to cleave its cognate substrate, SREBP2. Our findings reveal...

The three SREBP isoforms, SREBP-1a, SREBP-1c and SREBP-2, have different roles in lipid synthesis. In vivo studies using transgenic and knockout mice suggest that SREBP-1c is involved in FA synthesis and insulin induced glucose metabolism (particularly in lipogenesis), whereas SREBP-2 is relatively specific to cholesterol synthesis.