2017年10月18日 · We describe a mechanism involving the WNT target gene SP5 that leads to termination of the transcriptional program initiated by WNT signaling. Integration of gene expression profiles of...

2017年10月18日 · We describe a mechanism involving the WNT target gene SP5 that leads to termination of the transcriptional program initiated by WNT signaling. Integration of gene expression profiles of wild-type and SP5 mutant cells with genome-wide SP5 binding events reveals that SP5 acts to diminish expression of genes previously activated by the WNT pathway.

2025年2月17日 · In combination with our findings, SP5 was identified as the novel linking element between mTOR and WNT/β-catenin signaling pathway, suggesting the potential of multi-pathway targeted therapies...

2016年3月11日 · Here, we show in mouse embryos and differentiating embryonic stem cells that Sp5/8 are gene-specific transcriptional coactivators in the Wnt/β-catenin pathway. Sp5/8 bind directly to GC boxes in Wnt target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1/lymphoid enhancer factor (Lef) 1 to ...

2014年3月9日 · Here we demonstrate that distinct functional states of Wnt activity determine oligodendrocyte precursor cell (OPC) differentiation and myelination. Mouse OPCs with genetic Wnt dysregulation...

2025年1月1日 · Recent studies have demonstrated sp5 activation by Wnt signaling in invertebrates including amphioxus, planarians, acoels, hydra and sea urchins. Table 1 summarizes key studies that highlight the well-known yet opposing roles of sp5 downstream of Wnt signaling in various organisms.

2005年3月29日 · sp5-like is a direct target of Wnt/beta-catenin signaling during gastrulation and, together with sp5, acts as a required mediator of the activities of wnt8 in patterning the mesoderm and neuroectoderm. We conclude that sp5 transcription factors mediate the downstream responses to Wnt/beta-catenin si …

2007年1月12日 · A proximal promoter of Sp5 gene is highly evolutionarily conserved and contains five TCF/LEF binding sites that mediate direct regulation of Sp5 expression by canonical Wnt signaling. We provide evidence that Sp5 works as a transcriptional repressor and has three independent repressor domains, called R1, R2, and R3, respectively.

强制 Sp5 表达可以重现 Wnt/β-连环蛋白信号传导的部分效应，但模拟 LIF-Stat3 信号传导的大部分特征以维持未分化的 mESC。 此外，Sp5能够将小鼠外胚层干细胞转化为幼稚多能状态。

2025年2月17日 · Mechanistically, WNT inhibitor- Specificity Protein (SP5) was delineated as facilitator of SERPING1 transcription by binding to the SERPING1 gene promoter.