Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6. [5][6] A related pseudogene has been identified on chromosome 1. Alternative splicing of this gene results in multiple transcript variants. [5] .

2025年3月30日 · SOD2 (Superoxide Dismutase 2) is a Protein Coding gene. Diseases associated with SOD2 include Microvascular Complications Of Diabetes 6 and Gastric Cancer. Among its related pathways are Gene expression (Transcription) and Defective Intrinsic Pathway for …

超氧化物歧化酶 （英語： superoxide dismutase，缩写 SOD）是一种能够催化 超氧化物 通过 歧化反应 转化为 氧气 和 过氧化氢 的 酶。 它广泛存在于各类 动物 、 植物 、 微生物 中，是一种重要的 抗氧化剂，保护暴露于氧气中的 细胞。 超氧化物歧化酶所催化的 超氧化物 的 歧化反应 可以分为两步： M n+ − SOD + O 2− + 2H + → M (n+1)+ − SOD + H 2 O 2. 其中，M可以表示 Cu (n=1)； Mn (n=2)； Fe (n=2)； Ni (n=2)。 在此反应中，金属离子M的 氧化态 在n和n+1之间来 …

Eukaryotic systems have evolved defenses against such damaging moieties, the chief member of which is superoxide dismutase (SOD2), an enzyme that efficiently converts superoxide to the less reactive hydrogen peroxide (H 2 O 2), which can freely diffuse cross the mitochondrial membrane. Loss of SOD2 activity can result in numerous pathological ...

2024年6月1日 · SOD2 is upregulated in periodontitis to defend against excessive intracellular ROS production. SOD2 exhibits tumor-suppressive or tumor-promoting effects in oral cancers. SOD2 has a preventive and therapeutic potential for common oral diseases.

该基因是铁/锰超氧化物歧化酶家族的成员。 它编码一种线粒体蛋白，形成同源四聚体，每个亚基结合一个锰离子。 这种蛋白质与氧化磷酸化的超氧化物副产物结合，并将它们转化为过氧化氢和双原子氧。 该基因的突变与特发性心肌病 (IDC) 、过早衰老、散发性运动神经元疾病和癌症有关。 该基因的可变剪接导致多个转录变体。 已在 1 号染色体上鉴定出一个相关的假基因。 [RefSeq 提供，2016 年 4 月] This gene is a member of the iron/manganese superoxide dismutase family.

2018年11月2日 · Mitochondrial superoxide dismutase 2 (SOD2) is a major antioxidant defense enzyme. Here we provide evidence that SOD2 plays critical roles in maintaining calcium homeostasis...

2025年2月8日 · Title: SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation. SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress …

2025年2月8日 · It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen.

Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats. SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation.