SOD1, which is mutated in one-fifth of people with familial amyotrophic lateral sclerosis, forms aggregates in those people and in animal models of the disease. In a paper published online …

2016年3月6日 · SOD1-G93A (congenic): This congenic line is derived from the original hybrid line by backcrossing to C57BL/6J mice. It is available through The Jackson Laboratory, Stock …

2018年8月8日 · Moreover, aggregated SOD1 promotes more ER stress, leading to a vicious cycle that could activate harmful responses in astrocytes, he proposed. This suggests that SOD1 …

2018年3月6日 · SOD1 (G37R) (congenic) - This congenic line is derived from line 29 and backcrossed to C57BL/6J. It is available through The Jackson Lab, Stock# 008229 . Some …

2018年7月19日 · SOD1-G93A mice treated with ASO1 at five weeks of age maintained innervation of the tibialis anterior muscles in the calf over the next 12 weeks, while 75 percent …

2016年1月16日 · SOD1 aggregates in mice injected with tissue homogenates containing the SOD1-G93A “strain” (right), but not buffer (left) or homogenates from SOD1-G85R mice …

new SOD1 antibodies. While this is an obvious study to do, it was not possible in the past because antibodies that are highly sensitive for misfolded SOD1 have only recently become …

2019年6月4日 · SOD1-G85R (congenic) - A congenic line (B6.Cg-Tg(SOD1*G85R)148Dwc/J) is available through The Jackson Lab, Stock# 008248; Cryopreserved. According to the JAX …

2018年5月4日 · Structural analysis of the compounds bound to SOD1 revealed that ebselen and ebsulphur form covalent selenylsulfide or disulfide bonds, respectively, with cysteine-111 on …

The company then screened 2,000 SOD1 ASOs and identified two targeting the mRNA 3' untranslated region that were most effective at lowering SOD1 mRNA and protein levels in …