Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene. [5] [6] SOCS1 orthologs [7] have been identified in several mammals for which complete genome data are available.

2018年4月19日 · SOCS proteins can act as ubiquitin ligases by recruiting Cullin5 to ubiquitinate signalling components; however, SOCS1, the most potent member of the family, can also inhibit JAK directly. Here...

2025年3月30日 · SOCS1 (Suppressor Of Cytokine Signaling 1) is a Protein Coding gene. Diseases associated with SOCS1 include Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency and Diffuse Large B-Cell Lymphoma. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Class I MHC mediated antigen processing and presentation.

2025年3月3日 · Lancet Rheumatology has published a population study of the rare suppressor of cytokine signalling 1 (SOCS1) insufficiency - an inborn error of immunity affecting the negative regulation of cytokine and growth factor signalling. It was first discovered in 2020.

In this review, we describe the mechanism of SOCS1 action, focusing on the role of SOCS1 in autoimmunity and cancer, and discuss the potential for new SOCS1-directed cancer therapies that could be used to enhance adoptive immunotherapy and immune checkpoint blockade. Keywords: SOCS1, cytokine, JAK-STAT, immunotherapy, autoimmunity, cancer. 1.

SOCS1 is a negative feedback regulator of cytokine and growth factor receptor signaling, and plays an indispensable role in attenuating interferon gamma signaling. Studies on SOCS1-deficient mice have established a crucial role for SOCS1 in regulating CD8 + T cell homeostasis.

Ferroptosis-related gene SOCS1, a marker for tuberculosis diagnosis and treatment, involves in macrophage polarization and facilitates bone destruction in tuberculosis.

2025年2月27日 · In 2020, suppressor of cytokine signalling 1 (SOCS1) insufficiency was added to the group of monogenetic immune dysregulatory disorders. 7–9 SOCS1 is a crucial negative regulator of Janus kinase (JAK)-STAT signalling, downregulating the activity of more than 30 cytokines and growth factors involved in immune responses—particularly those ...

The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK-STAT signaling pathways.

2007年5月18日 · Suppressor of cytokine signalling (SOCS) proteins are inhibitors of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathways. SOCS1 also inhibits Toll-like...