2025年3月30日 · SNX1 (Sorting Nexin 1) is a Protein Coding gene. Diseases associated with SNX1 include Spinocerebellar Ataxia, Autosomal Recessive 10 and Parkinson Disease, Late-Onset. Among its related pathways are Posttranslational regulation of adherens junction stability and dissassembly and PAR1-mediated thrombin signaling events.

2021年3月9日 · The sorting nexin (SNX) family of proteins deform the membrane to generate transport carriers in endosomal pathways. Here, we elucidate how a prototypic member, SNX1, acts in this process. Performing cryoelectron microscopy, we find that SNX1 assembles into a protein lattice that consists of helical …

SNX1 is a component of the retromer complex. [6][7] This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor.

2024年12月26日 · 本文将详细介绍SNX1基因的功能、作用机制、信号通路及其与疾病的关系，帮助读者全面了解这一重要的基因。 SNX1，全称为sorting nexin 1，是一个位于人类染色体15q22.31的基因，编码蛋白质产品。 它属于Sorting nexins家族，这个家族的成员都含有PX-BAR域。 SNX1在细胞内扮演着关键的角色，特别是在内吞作用和囊泡运输过程中。 SNX1主要负责调控内吞途径中的囊泡运输和分类。 具体来说，它帮助确保合适的分子被运输到正确的细 …

2021年3月4日 · 该研究解析了细胞内体运输途径中包被蛋白Sorting nexin 1（SNX1）在细胞膜上的分子组装模式，阐释了SNX1重塑细胞膜变形的分子机理。 囊泡运输（esicle trafficking）是真核细胞内膜性细胞器之间主要的物质运输方式，既是生命活动的基本过程，又是极其复杂的动态 ...

2021年3月3日 · Performing cryoelectron microscopy, we find that SNX1 assembles into a protein lattice that consists of helical rows of SNX1 dimers wrapped around tubular membranes in a crosslinked fashion. We also visualize the details of this structure, which provides a molecular understanding of how various parts of SNX1 contribute to its ability to deform ...

Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes.

Title: MiR-95 induces proliferation and chemo- or radioresistance through directly targeting sorting nexin1 (SNX1) in non-small cell lung cancer. Results show that suppression of EGFR membrane recycling by SNX1 appears to be critical for the activation of EGFR /PI3K/AKT signaling pathway in human lung cancer cells.

2019年10月1日 · SNX5 and SNX6 are now revealed to decode a conserved bipartite signal to mediate protein sorting to the Golgi or the plasma membrane. Endosomes are critical sorting hubs for proteins synthesized in...

Here a detailed expression and purification protocol of the SNX1/SNX6 complex, from both worm and human, is described. Keys to the successful protein production include co-expression of both genes, and inclusion of glycerol in the protein buffer. Solution studies suggest that SNX1 and SNX6 form a 1:1 heterodimer.