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2024年5月8日 · Herein, we present a promising strategy based on dexamethasone liposome-integrated MSCs (Dexlip-MSCs) for treating SLE via multiple immunomodulatory pathways. This therapeutic strategy prolonged the circulation time of dexamethasone liposomes in vivo , restrained CD4 + T-cell proliferation, and inhibited the release of proinflammatory mediators ...

2024年5月21日 · The therapeutic application of mesenchymal stem cells (MSCs) has good potential as a treatment strategy for systemic lupus erythematosus (SLE), but traditional MSC therapy still has limitations in effectively modulating immune cells. Herein, we present a promising strategy based on dexamethasone lip …

系统性红斑狼疮（sle）是一种严重的自身免疫性疾病，其特点是自身抗体积累、免疫复合物沉积以及免疫耐受失败导致各种靶器官出现炎症性损伤。 自身抗体，尤其是抗 Sm、抗 dsDNA 和抗 RNP 抗体被认为是 SLE 的标志，与疾病进展密切相关。

2024年7月15日 · Understanding the pathogenesis and clinical manifestations of systemic lupus erythematosus (SLE) has been a great challenge. Reductionist approaches to understand the nature of the disease have...

2024年5月7日 · Importance: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by inflammation and immune-mediated injury to multiple organ systems, including the mucocutaneous, musculoskeletal, hematologic, and kidney systems. Approximately 3.4 million people worldwide have received a diagnosis of SLE.

系统性红斑狼疮 是一种慢性的累及多系统的炎症性疾病，病因为自身免疫性，主要发生于年轻女性。 常见表现可包括多关节痛和关节炎、雷诺综合征、面颊及其他部位皮疹、胸膜炎或心包炎、肾脏或中枢神经系统受累以及自身免疫性细胞减少。 诊断依靠临床和血清学检查。 治疗严重的、持续的活动性疾病需要糖皮质激素和免疫抑制剂。 SLE患者中70%～90%为女性（主要为育龄期女性）。 系统性红斑狼疮（SLE）在黑人和亚裔患者中比白人患者更为常见和严重。 可见于任何 …

2023年1月27日 · Here, we review the classification criteria as well as standard and emerging diagnostic tools available to identify patients with SLE. We then focus on medical management, including novel therapeutics, nonpharmacologic interventions, and comorbidity management.

2023年8月4日 · Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multisystem involvement and is associated with significant morbidity and mortality. Genetic, immunological, endocrine, and environmental factors influence the loss of immunological tolerance against self-antigens leading to the formation of pathogenic autoantibodies that ...

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement. It is multifactorial and involves epigenetic, genetic, ecological, and environmental factors. Primarily it leads to activation of both innate and ...