2017年7月13日 · What is SLC6A4? The serotonin transporter, encoded by the SLC6A4 gene, is responsible for serotonin reuptake into the presynaptic neuron. While many antidepressants …

2025年3月30日 · SLC6A4 (Solute Carrier Family 6 Member 4) is a Protein Coding gene. Diseases associated with SLC6A4 include Obsessive-Compulsive Disorder and Anxiety. Among its related pathways are Transmission across Chemical Synapses and Nuclear receptors meta-pathway.

The gene that encodes the serotonin transporter is called solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4, see Solute carrier family).

Learn about SLC6a4 gene mutation and how it affects your immediate response to stress and antidepressants. This can help you reduce your stress levels!

2019年5月13日 · Gene-by-environment interactions: Negative life events only lead to depression in individuals with a specific genetic set-up that makes them risk-prone to develop depression. The gene most commonly...

Gene ID: 6532, updated on 8-Feb-2025. This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner.

The human serotonin transporter (SERT) is encoded by a single gene (SLC6A4) located on the long arm of chromosome 17 (17q11-17q12).

In vivo, SLC6A4 variants in humans and other species lead to marked physiological changes, despite mitigating neurodevelopmental adaptations in 5-HT receptors plus compensatory alterations in 5-HT synthesis and metabolism.

2012年5月10日 · This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner.

2010年12月2日 · The SLC6A4 gene encodes the serotonin transporter, a membrane protein that takes up serotonin in pre-synaptic neurons. SLC6A4 is also known as SERT or 5-HTT, since serotonin is known chemically as 5-hydroxytryptamine.