2025年3月30日 · SLC40A1 (Solute Carrier Family 40 Member 1) is a Protein Coding gene. Diseases associated with SLC40A1 include Hemochromatosis, Type 4 and Hemochromatosis Type 2 . Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Disorders of transmembrane transporters .

Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded by the SLC40A1 gene. [5] Ferroportin is a transmembrane protein that transports …

Abstract: Ferroportin (FPN, SLC40A1) is the membrane localized sole known iron exporter in mammals, which plays an important role for regulating iron homeostasis via exporting cellular ferrous iron. Recently, emerging studies suggest FPN possesses critical physiological functions, such as cell metabolism, cell fate and ferroptosis. In

slc40a1是slc40家族的唯一成员，并且参与了所描述的唯一的细胞铁外排机制。 SLC40A1在人体铁稳态中起关键作用的几种组织和细胞中高度表达。 讨论了在转录，转录后和翻译后水平调控SLC11A2和SLC40A1表达的信号传导途径。

2023年10月2日 · SLC40A1 translation is inhibited by iron-regulatory proteins (IRPs) binding to iron-responsive elements (IREs) in its 5′ untranslated region (UTR), whereas microRNAs (miRs) reduce SLC40A1 mRNA...

2024年3月20日 · Solute carrier family 40 member 1 (SLC40A1) plays an essential role in transporting iron from intracellular to extracellular environments. When SLC40A1 expression is abnormal, cellular iron metabolism becomes dysregulated, resulting in an overload of intracellular iron, which induces cell ferroptosis.

铁泵蛋白(Ferroportin, FPN/SLC40A1)是目前哺乳动物中唯一已知的铁外排膜蛋白,在调控机体铁稳态代谢过程中发挥重要作用.近年,围绕FPN蛋白转运铁离子生理功能及其分子调控机制方面取得了令人瞩目的研究进展.FPN蛋白通过从细胞内向外转运Fe参与许多关键生理过程,如 ...

与人类 slc40a1（溶质载体家族 40 成员 1）直向同源。 [由基因组资源联盟提供，2022 年 4 月] Enables ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity.

2024年3月20日 · Solute carrier family 40 member 1 (SLC40A1) plays an essential role in transporting iron from intracellular to extracellular environments. When SLC40A1 expression is abnormal, cellular iron metabolism becomes dysregulated, resulting in an overload of intracellular iron, which induces cell ferroptosis.

Ferroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release. Hepcidin, a regulatory peptide, binds to ferroportin and causes it to be internalized and degraded.