Sirtuin 6 - Wikipedia
Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [5] [6] [7] In laboratory research, …
《Nature》最新研究：SIRT6 或可帮助人类寿命达120岁！ - 知乎
SIRT6属于SIRT2蛋白家族中的一员，目前已知其拥有 NAD+ 依赖的 组蛋白去乙酰化酶 和 单ADP核糖基转移酶 两种功能。 SIRT6 通过这两种功能在调控DNA修复、 端粒维护 、葡萄糖 …
SIRT6 is a key regulator of mitochondrial function in the brain
2023年1月18日 · SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global downregulation of mitochondria-related genes and pronounced changes in metabolite content. …
SIRT6: Novel Mechanisms and Links to Aging and Disease
SIRT6, a member of the Sirtuin family of NAD +-dependent enzymes, has established roles in chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …
长寿蛋白SIRT6在肿瘤发生发展中的作用 - Chinese Journal of ...
SIRT6作为组蛋白去乙酰化转移酶 (Histone deacetylases，HDACs) 第三家族长寿蛋白 (Sirtuins，SIRTs) 中的一员，具有多种催化酶活性，且在抗衰老、染色质调节、转录调控、糖 …
SIRT6 Widely Regulates Aging, Immunity, and Cancer - PMC
SIRT6 is a longevity protein that can inhibit the aging of cells, tissues, organs and the body by promoting DNA damage repair (5 – 7), maintaining normal chromosome structure (8 – 10), …
SIRT6 is a histone H3 lysine 9 deacetylase that modulates ... - Nature
2008年3月12日 · Here we show that the human SIRT6 protein is an NAD + -dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates …
SIRT6在DNA损伤修复中的新功能 - 知乎 - 知乎专栏
sirt6 是肿瘤与衰老发生中的关键调控因子，此前多项研究已经证明sirt6可通过参与调控 dsbr 等通路从而维持基因组稳定性。 然而，SIRT6 是否参与 NER 以及潜在的调控机制仍然缺乏系统深 …
长寿蛋白SIRT6在衰老和代谢中作用的研究进展
SIRT6, a member of the sirtuin family of histone deacetylases, belongs to the class Ⅲ longevity proteins and exhibits NAD +-dependent deacetylase and mono-ADP-ribosyltransferase …
sirt6 主要位于细胞核内，可通过核心调控基因组稳定性和相关基因表达，参与控制机体能量代 谢和衰老在内的关键过程。 鉴于其在维持细胞稳态和机体健康中的关键作用，SIRT6 作为潜在的 …