Sirtuin 4 - Wikipedia
Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. [5][6] SIRT4 is member of the mammalian sirtuin family of proteins, which are …
SIRT4 Gene - GeneCards | SIR4 Protein | SIR4 Antibody
2025年3月30日 · SIRT4 (Sirtuin 4) is a Protein Coding gene. Diseases associated with SIRT4 include Renu Syndrome and Hyperinsulinemic Hypoglycemia, Familial, 6. Among its related …
寿命的秘密-长寿基因Sirtuins家族 - 知乎 - 知乎专栏
2023年8月2日 · Sirtuins是广泛分布于细胞中的一种去乙酰化酶类，简单来说，就是 由一群蛋白质组成的长寿蛋白大家族，共有7个亚型SIRT1~SIRT7。 Sirtuins蛋白在细胞抗逆性、能量代谢 …
Amino acids downregulate SIRT4 to detoxify ammonia through …
2023年4月17日 · Ammonia production via glutamate dehydrogenase is inhibited by SIRT4, a sirtuin that displays both amidase and non-amidase activities. The processes underlying the …
代谢学人——Nature Metabolism：氨中毒，SIRT4前来救驾 - 知乎
已知线粒体中的Sirtuins包括SIRT3、SIRT4、SIRT5等，通过对多种Sirtuins进行验证，研究人员发现仅在过表达SIRT4后可以发挥去CP-K修饰功能，引起HepG2细胞线粒体中CP-K水平下调（ …
Frontiers | Sirt4: A Multifaceted Enzyme at the Crossroads of ...
2020年4月15日 · For its capability to inhibit glutamine catabolism and for the modulation of genome stability in cancer cells in response to different DNA-damaging conditions, Sirt4 is …
Sirtuin 4 Is a Lipoamidase Regulating Pyruvate ... - Cell Press
The major catalytic activity of the mitochondrial sirtuin, SIRT4, is as a lipoamidase rather than a deacetylase. SIRT4 hydrolyzes lipoamide modifications on the pyruvate dehydrogenase …
Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial ...
2020年4月15日 · For its capability to inhibit glutamine catabolism and for the modulation of genome stability in cancer cells in response to different DNA-damaging conditions, Sirt4 is …
Functions of mammalian SIRT4 in cellular metabolism and …
SIRT4 has been shown to play a crucial role in insulin secretion, fatty acid oxidation, amino acid metabolism, ATP homeostasis, apoptosis, neurodegeneration, and cardiovascular diseases. In …
The Roles of Mitochondrial SIRT4 in Cellular Metabolism
SIRT4 is critical for cellular metabolism and DNA damage responses in mitochondria. SIRT4 contains an N-terminal mitochondrial signal sequence that directs of its localization to …