Sirt3-KO - 南模生物
敲除Sirt3基因的exon 2-3 区域，获得Sirt3基因敲除小鼠模型。 应用领域 ：免疫相关 *使用本品系发表的文献需注明: Sirt3-KO mice (Cat. NO. NM-KO-190368) were purchased from Shanghai …
Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1 ...
2024年10月18日 · We quantitatively analyzed the Kla and Kac proteomes in wildtype (WT), SIRT1 knockout (KO), and SIRT3 KO HepG2 cells, successfully identifying 8075 Kla sites and …
Mitochondrial Sirtuin 3: New emerging biological function and ...
Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism …
上海药物所黄河：SIRT1/3是乳酸化修饰“eraser” - 搜狐
2024年10月10日 · 通过对野生型(WT)、SIRT1 敲除(knockout, KO)和SIRT3 KO的HepG2细胞进行了乳酸化和乙酰化修饰组学检测，研究分别鉴定到8075个Kla位点和3515个Kac位点。分析发 …
Mitochondrial SIRT3 as a protective factor against ... - Nature
2024年5月2日 · Sirtuin3 (SIRT3), a mitochondrial deacetylase, has been shown to be involved in various kidney diseases. In this study, we aimed to clarify the role of SIRT3 in cyclosporine …
内皮特异性SIRT3缺失会损害糖酵解和血管生成，并导致舒张功能 …
在体内，内皮特异性sirt3 ko（ecko）小鼠表现出心肌毛细血管稀疏性以及降低的冠状动脉血流储备（cfr）和舒张功能障碍。 组织学研究进一步表明，敲除ECS中的SIRT3会显着增加冠状动脉 …
Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and ...
SIRT3 regulates cardiac ATP generating pathways by altering the lysine acetylation of numerous mitochondrial enzymes. In SIRT3 KO mice, over 84 cardiac mitochondrial proteins are …
Sirtuin 3 regulates mitochondrial protein acetylation and
2021年9月13日 · We found that decreased SIRT3 expression was accompanied by increased acetylation in mitochondria that have separated from TECs during the early phase of renal …
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by …
2016年3月1日 · In this study, we showed a new role for SIRT3 in retarding aging-associated tissue fibrosis. Sirt3-KO mice developed increased blood pressure and had exacerbated tissue …
Emerging role of SIRT3 in endothelial metabolism, angiogenesis …
Emerging evidence indicates that SIRT3 is involved in the regulation of endothelial metabolism and angiogenesis and thus affects the development of cardiovascular diseases associated …