NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 …

SIRT3基因研究概况. SIRT3是哺乳动物 sirtuin蛋白家族 的成员，表现出 NAD+ 依赖性脱乙酰酶活性。人类sirtuins具有一系列分子功能，并已成为衰老，抗逆性和代谢调节中的重要蛋白质。

2025年3月30日 · SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, …

sirt3、sirt4和sirt5位于线粒体中，可以缓和线粒体的氧化应激： SIRT3：参与角质形成细胞分化、伤口愈合、衰老、紫外线辐射/臭氧反应、系统性硬化症、黑色素瘤、基底细胞癌和鳞状细胞癌。

Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism …

SIRT3 is a NAD +-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an …

SIRT3 (sirtuin 3，SIRT3)是一种保守的依赖于NAD+ (NAD+)的脱乙酰酶，位于线粒体中，可能调节氧化应激、分解代谢和ATP的产生。 最近越来越多的证据表明，SIRT3通过其去乙酰化修饰在 …

2025年2月1日 · SIRT3 regulates glucose uptake in cardiomyocytes and improves cardiac function in heart failure caused be blood pressure overload (Zeng et al., 2020). SIRT3 also has a key …

SIRT3 encodes a member of the Sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can …

2014年2月6日 · SIRT3, a major mitochondrial NAD + -dependent deacetylase, has a key role in cancer. The function of SIRT3 may be different depending on the cell-type and tumor-type; …