SIRT2: Controversy and multiple roles in disease and physiology
This review summarizes the functions of SIRT2 in the nervous system, mitosis regulation, genome integrity, cell differentiation, cell homeostasis, aging, infection, inflammation, oxidative stress, …
SIRT2 Gene - GeneCards | SIR2 Protein | SIR2 Antibody
2025年3月30日 · SIRT2 (Sirtuin 2) is a Protein Coding gene. Diseases associated with SIRT2 include Primary Hyperoxaluria and Thrombocytopenia. Among its related pathways are Cell …
Multiple Roles of SIRT2 in Regulating Physiological and …
Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. …
Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of ...
2021年5月23日 · As a type of nicotinamide adenine dinucleotide (NAD +)-dependent deacetylases, sirtuin 2 (SIRT2) is predominantly found in the cytoplasm of cells in the central …
SIRT2 as a Therapeutic Target for Age-Related Disorders - PMC
Here we focus on SIRT2, a member of the sirtuin family, and discuss its role in cellular and tissue-specific functions. This review summarizes the main scientific advances on SIRT2 protein …
Structure, functions, and recent advances in the development of SIRT2 …
2023年12月1日 · Among the seven human sirtuins, sirtuin 2 (SIRT2) is one of the most studied and plays important roles in cell aging, energy metabolism, and genome stability. SIRT2 …
Human Sirtuin 2 Localization, Transient Interactions, and ... - PubMed
Human sirtuin 2 (SIRT2) is an NAD +-dependent deacetylase that primarily functions in the cytoplasm, where it can regulate α-tubulin acetylation levels. SIRT2 is linked to cancer …
SIRT2 functions as a histone delactylase and inhibits the …
2022年6月7日 · A recent study showed that SIRT2 can remove the lactyl group from synthetic peptides related to pyruvate kinase M2 (PKM2) 5. It is therefore possible that some sirtuins …
22933 - Gene ResultSIRT2 sirtuin 2 [ (human)] - National Center for ...
2025年2月8日 · SIRT2 tyrosine nitration by peroxynitrite in response to renal ischemia/reperfusion injury. The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in …
SIRT2 regulates extracellular vesicle-mediated liver–bone ... - Nature
2023年5月15日 · Liver-specific SIRT2 deficiency inhibits osteoclastogenesis and alleviates bone loss in mouse models of osteoporosis. We identify leucine-rich α-2-glycoprotein 1 (LRG1) as a …
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