SHP2 是 PTP 家族中第一个被证实的原癌蛋白，是生长因子信号通路和免疫检查点信号通路的重要调节因子，参与 Ras/Raf/MEK/ERK 、 JAK/STAT 、 PI3K/AKT/mTOR 和 PD-1/PD-L1 等多 …

This review focuses on the roles of the two cytoplasmic PTPs, the Src-homology 2 domain (SH2)-containing SHP-1 and SHP-2, in T-cell signaling, development, differentiation, and function. …

2022年11月21日 · 含srC同源-2的蛋白酪氨酸磷酸酶2（SHP2），由PTPN11编码，是一种去磷酸化酶，属于蛋白酪氨酸磷酸酶（PTPs）家族。 SHP2作为包括Ras-Raf-MEK-ERK、JAK …

Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues. SHP2 …

2000年12月1日 · SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is involved in the signaling pathways of a variety of growth factors and cytokines.

2024年3月4日 · SHP-2 is a key intracellular regulatory factor mediating cell proliferation and differentiation and is involved in a variety of growth factor and cytokine signaling pathways …

1998年5月1日 · SHP-2, also known as PTP1D, SHPTP-2, SHPTP-3, PTP2C or Syp, is an ubiquitously expressed cytosolic protein tyrosine phosphatase (PTP) containing two src …

2020年2月1日 · Several studies have shown that SHP2 plays an important role in regulating immune cell functions in tumor microenvironment. A few clinical trials conducted using SHP2 …

2022年12月29日 · Boussiotis and colleagues show that the tyrosine phosphatase SHP-2 regulates the differentiation and antitumor function of monocytes downstream of the inhibitory …

2020年10月22日 · SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. …