SHP-1 作为 PTP 中重要的一员，是改变胞内磷酸化水平的关键因子，当外源性信号分子同胞膜上受体结合后激发受体分子二聚化，与受体耦联的两面神激酶（JAK）互相靠拢，通过彼此的酪氨酸磷酸化而活化，活化后 JAK 催化受体自身的酪氨酸磷酸化，形成了 SHP-1 的停泊位点。 SHP-1 与受体上的停泊位点结合而被激活，催化 JAK 的酪氨酸去磷酸化，降低激酶催化活性，进而终止信号传导。 但具体而言， SHP-1 其在不同的细胞中可产生不尽相同的胞内信号，本文从以下各种 …

Dec 2, 2024 · SHP1和SHP2是非受体蛋白酪氨酸磷酸酶（nonreceptor protein tyrosine phosphatase）家族蛋白成员，对造血和免疫系统的正常发育和功能调节至关重要，同时在肿瘤、淋巴瘤和白血病等疾病中频繁出现突变或者表达水平降低。 文章回顾了SHP1和SHP2在造血、免疫系统发育和功能调控方面的作用，重点讨论了抑制SHP1和SHP2减少肿瘤发生、化疗耐药，同时促进免疫监视，从而双管齐下地增强抗肿瘤的治疗效果。 有兴趣在 Trends in Cell Biology 发 …

Feb 6, 2024 · Here we demonstrate that inhibition of tyrosine phosphatase SHP-1 in LSCs increases their glycolysis and oxidative phosphorylation, enhancing their sensitivity to chemotherapy and vulnerability...

SHP-1 [protein tyrosine phosphatase, non-receptor type 6 (PTPN6)] is expressed by all mature haematopoietic lineages and at low levels, in a different isoform, by endothelial cells . There is 95% homology between human and mouse SHP-1, …

Apr 15, 2016 · This review will discuss the potential value of SHP-1 inhibition in future tumour immunotherapy. Keywords: SHP-1; adoptive cell transfer; checkpoint inhibitors; protein tyrosine phosphatase inhibition; tumour immunotherapy.

SHP-1 or PTPN6 (previously also referred to as SH-PTP1, PTP1C, HCP, or Hcph) is expressed predominantly in hematopoietic cells of all lineages and all stages of maturation, while it is expressed at low levels in epithelial cells (21, 26–28, 31).

Apr 21, 2024 · Detailed studies have shown that SHP-1 regulates SHP2 expression, and SHP-1 and SHP2 are involved in macrophage M2 polarisation. SHP-1 inhibits HOXA10 and TGFβ2 which in turn regulates the...

Mar 13, 2003 · SHP-1, an SH2 domain-containing protein tyrosine phosphatase, is primarily expressed in hematopoietic cells and behaves as a key regulator controlling intracellular phosphotyrosine levels in lymphocytes.

Apr 11, 2023 · During education, inhibitory receptors sequestered SHP-1, suggesting a model in which SHP-1 is prevented from accumulating at activating immune synapses between NK cells and their targets, thus facilitating target cell killing.

Aug 15, 2018 · Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1, also known as PTPN6) is a nonreceptor protein tyrosine phosphatase that acts as a negative regulator of inflammation. Emerging evidence indicates that SHP-1 plays a role in inhibiting the progression of hepatocellular carcinoma (HCC …