2025年3月30日 · SHB (SH2 Domain Containing Adaptor Protein B) is a Protein Coding gene. Diseases associated with SHB include Sulfhemoglobinemia and Febrile Seizures, Familial, 4. Among its related pathways are Signaling by VEGF and Development VEGF signaling via VEGFR2 - generic cascades.

SH2 domain-containing adapter protein B is a protein that in humans is encoded by the SHB gene. [5] [6]

The tamoxifen-responsive conditional Cdh5-CreERT2 is commonly used for endothelial cell specific conditional deletion of loxP-flanked gene sequences. To address the role of endothelial cell Shb gene for B16F10 melanoma immune responses, ...

This article provides a resource for the available molecular tools that can be used in future research on Shb; It is concluded that tumor SHB gene expression relates to acute myeloid leukemia survival; SHB plays a role in integrating adaptive responses to various stimuli by simultaneously modulating cellular responses in different cell-types ...

SHB (Src homology 2 domain-containing adapter protein B) is a ubiquitously expressed SH2-domain adapter protein that has not previously been investigated for a role in oocyte maturation. It is involved in receptor tyrosine kinase signaling in many tissues by generating signaling complexes in response to receptor activation [8], [9].

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling.

2023年11月5日 · Tumor SHB gene expression affects disease characteristics in human acute myeloid leukemia. The role of the Src Homology-2 domain containing protein B (SHB) in β cells. SHB and angiogenic factors promote ES cell differentiation to insulin-producing cells. Saldeen J, Kriz V, Agren N, Welsh MSaldeen J, et al. Biochem Biophys Res Commun, 2006 Jun 2.

This gene has 1 transcript (splice variant), 122 orthologues and 3 paralogues. Ubiquitous expression in liver (RPKM 4.9), kidney (RPKM 3.8) and 25 other tissues. 功能概要

Adaptor proteins are molecules with multiple protein interaction motifs that do not appear to have catalytic activity of their own but mediate the interaction of other proteins. The SHB gene encodes 2 such adaptor proteins (from 2 different start methionines) of 67 and 56 kD (Welsh et al., 1994).

摘要: 目的 通过对乳腺癌组织和健康人外周血中SHB(Src homology 2 domain containing adaptor protein B，SHB)基因的单核苷酸多态（single nucleotide polymorphism SNP）进行检测，研究SHB基因与乳腺癌的相关性。方法 对SHB基因的启动子、外显子以及临近的内含子区域，使用PCR扩增和DNA ...