2016年6月1日 · Spiral ganglion neuron (SGN) afferent fiber responses are determined peripherally. Proteins of the SGN postsynapse and neighboring cells shape glutamatergic signaling. Ion channels and transporters set SGN excitability intrinsically. Input from the lateral olivocochlear efferent terminals modifies excitability.

2023年2月27日 · Runx1 is necessary for generation of Ib/Ic spiral ganglion neuron (SGN) subtype identities. Runx1 loss has broader effect on genes related to neural function than to connectivity. Postnatal deletion of Runx1 switches SGN identity. Overabundance of Ia SGNs results in enhanced auditory nerve response.

2023年2月27日 · Runx1 is necessary for generation of Ib/Ic spiral ganglion neuron (SGN) subtype identities. Runx1 loss has broader effect on genes related to neural function than to connectivity. Postnatal deletion of Runx1 switches SGN identity. Overabundance of Ia SGNs results in enhanced auditory nerve response.

In the mammalian cochlea, spiral ganglion neurons (SGNs) are the primary neurons on the auditory conduction pathway that relay sound signals from the inner ear to the brainstem. However, because the SGNs lack the regeneration ability, degeneration and loss of SGNs cause irreversible sensorineural hearing loss (SNHL).

The abbreviation SGN refers to Spiral Ganglion Neurons, which are critical components in the auditory system, transmitting sound information from the inner ear to the brain. These neurons play a significant role in hearing and are involved in the processing of auditory signals.

2014年2月14日 · The correlation between SGN density and ABR wave I amplitude underscores the possible interactions between SGN survival and ABR deficits and impaired cochlear function in the aging auditory system. Our study revealed that SGNs decrease with age in apical, middle and basal regions, with the basal area most affected.

2023年10月26日 · These findings make studies possible to conveniently identify SGN cell types and investigate the comprehensive distribution pattern of different SGN subtypes across tonotopic axis. In this study, we used immunohistochemistry to identify various SGN subtypes in cryo-sectioned cochlea by simultaneously staining three molecular markers of Tuj1, CR ...

2021年10月26日 · Spiral ganglion neurons (SGNs) can be injured by a wide variety of insults. However, there still is a lack of degeneration models to specifically damage the SGNs without disturbing other types of cells in the inner ear. This study aims to generate an SGN-specific damage model using the Cre-LoxP transgenic mouse strains.

2023年4月28日 · Spiral ganglion neurons (SGNs) transmit sensory data from cochlear hair cells to the cochlear nuclei of the brainstem. Loss of these neurons deprives the brain of information on sound, so functioning SGNs are necessary both for normal hearing and for the restoration of hearing with cochlear prostheses.

团队通过进行听觉脑干反应（ABR）记录来表征动物的SGN功能，发现Runx1CKO小鼠在阈值以上声压水平的P1振幅更大，转化为更陡峭的增长函数时，Runx1CKO与同窝对照相比，坡度增加范围为1.5至2.7倍。 这些数据表明Runx1带来的基因分子变化具有功能性的影响，具有Ia同一性的SGN的 增多导致具有更多高自发频率（Spontaneous Rate，SR） SGN的耳蜗的ABR反应。 团队通过对Runx1CreER/； Ai14/+小鼠在P1-P3给予他莫昔芬，然后在P27-P29收 …