2025年3月30日 · SGK3 (Serum/Glucocorticoid Regulated Kinase Family Member 3) is a Protein Coding gene. Diseases associated with SGK3 include Immunodeficiency 55 and Hypophosphatemic Rickets. Among its related pathways are Ion channel transport and PI3K-Akt signaling pathway.

This gene is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport …

2025年2月8日 · SGK3 is an estrogen receptor (ER) transcriptional target and promotes estrogen-mediated cell survival of ER-positive breast cancer cells. SGK3 is not required for insulin-induced PFK-2 activation and that this effect is likely mediated by PKBalpha.

2023年11月3日 · 本研究报道了 SGK3作为一种抗氧化因子在PIK3CA螺旋结构域突变的宫颈癌中促进细胞生长和耐药。 在机制上，SGK3在 氧化应激 时被激活，并通过稳定和激活抗氧化酶过氧化氢酶来发挥抗ROS活性。 SGK3与过氧化氢酶相互作用并磷酸化过氧化氢酶，促进其四聚体状态和活性。 同时，SGK3磷酸化GSK3β，保护过氧化氢酶免受GSK3β-β-TrCP介导的 泛素化 和蛋白酶体降解。 此外， SGK3抑制不仅增强了CDK4/6抑制剂Palbociclib介导的细胞毒性，还通 …

2018年7月23日 · SGK family consists of three isoforms (SGK1, SGK2, and SGK3), which have high sequence homology in the kinase domain and similar substrate specificity with the AKT family.

2024年2月18日 · 一、SGK3蛋白的基本信息： SGK3（Serine/Threonine Kinase 3）是一种重要的丝氨酸/苏氨酸激酶，在细胞存活、增殖和代谢调节中发挥重要作用。该蛋白属于AGC（PKA、PKG、PKC蛋白激酶家族）磷酸化酶群，并由人类基因SGK3编码。

2018年9月1日 · SGK is a family consisting of three isoforms: SGK1, SGK2, and SGK3 encoded by the genes SGK1, SGK2 and SGK3, respectively, and they are activated downstream of the PI3K pathway 5. The SGK isoforms are highly similar in structure, with almost 80% sequence identity within the catalytic domains and almost 50% within the C-terminus region.

该基因是 Ser/Thr 蛋白激酶家族的成员，编码具有 PX (phox 同源) 结构域的磷蛋白。 该蛋白磷酸化几种靶蛋白，并在中性氨基酸转运和钾通道和氯通道激活中发挥作用。 已经表征了编码不同亚型的替代转录剪接变体。 [RefSeq 提供，2008 年 7 月] This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain.

2019年9月20日 · SGK3 is a PX domain containing protein kinase activated at endosomes downstream of class 1 and 3 PI3K family members by growth factors and oncogenic mutations. SGK3 plays a key role in mediating resistance of breast cancer cells to class 1 PI3K or Akt inhibitors, by substituting for the loss of Akt …

2019年4月11日 · Serum and glucocorticoid kinase 3 (SGK3) belongs to the SGK family of AGK kinases and functions in parallel to AKT downstream of PI3K. Previous studies have shown that SGK3 may be the major kinase responsible for the oncogenic potential of PIK3CA helical domain mutants, such as PIK3CA (E545K), but not kinase domain mutants, such as PIK3CA (H1047R).