Histone-lysine N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene. [5][6] SETDB1 is also known as KMT1E or H3K9 methyltransferase ESET. The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure.

2025年3月30日 · SETDB1 (SET Domain Bifurcated Histone Lysine Methyltransferase 1) is a Protein Coding gene. Diseases associated with SETDB1 include Huntington Disease and Hyperoxaluria, Primary, Type I. Among its related pathways are Regulation of endogenous retroelements and PKMTs methylate histone lysines.

2021年8月11日 · The SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) is a prominent member of the Suppressor of Variegation 3-9 (SUV39)-related protein lysine methyltransferases (PKMTs), comprising three isoforms that differ in length and domain composition. SETDB1 is widely expressed in human tiss …

2021年5月5日 · SETDB1 represses broad domains, primarily within the open genome compartment. These domains are enriched for transposable elements (TEs) and immune clusters associated with segmental duplication...

2020年4月22日 · SET domain, bifurcate 1 (SETDB1), functioning as a histone H3K9 specific methyltransferase, is not only critically involved in transcriptional silencing and local heterochromatin...

2022年1月13日 · 研究表明，甲基转移酶SETDB1引起组蛋白赖氨酸甲基化是几种癌症基因调控的共同特征，SETDB1异常活性与各种癌症的发展有关。 SETDB1可通过下调关键抑癌基因发挥促癌作用，然而，在特定的癌症和分型中，SETDB1也可产生相反效应。 2021年，Dimitrios Strepkos等人在《Cancer research》上发表了一篇题为《Histone Methyltransferase SETDB1: A Common Denominator of Tumorigenesis with Therapeutic Potential》的综述，对SETDB1活性 …

SETDB1 immune functions include B cell maturation, T cell activity regulation, and immune escape in cancer cells. In B lymphocytes, SETDB1 mediates the transition from pro-B to pre-B cells and represses endogenous retroviruses (ERV) to …

2024年1月2日 · SETDB1 is an essential histone methyltransferase that deposits histone H3 lysine 9 trimethylation (H3K9me3) to transcriptionally repress genes and repetitive elements. The...

In this review, we provide an overview of the complex biology of SETDB1, review the upstream regulatory mechanisms of SETDB1 and its partners, discuss the functions and molecular mechanisms of SETDB1 in cell fate determination and stem cell, as …

该基因编码组蛋白甲基转移酶，该酶调节组蛋白甲基化、基因沉默和转录抑制。 鉴于基因沉默和转录功能障碍可能在疾病发病机制中发挥作用，该基因已被确定为治疗亨廷顿病的靶标。 已经描述了该基因的可变剪接转录变体。 [RefSeq 提供，2011 年 6 月] This gene encodes a Histone Methyltransferase which regulates histone methylation, gene …