2023年3月10日 · Here we identify heightened mTORC1-associated gene expression programs and functionally higher levels of oxidative metabolism and protein synthesis as prominent …

2018年3月12日 · In this study, using a conditional Setd2 knockout mouse model, we show that Setd2 deficiency skews hematopoietic differentiation and reduces the number of multipotent …

2021年3月4日 · Our findings demonstrate that SETD2, by interacting with Pol II as well as hnRNP L, can mediate the crosstalk between the transcription and the splicing machinery. Alternative …

2023年2月22日 · Using conditional Setd2-KO mice, we demonstrated that Setd2 deficiency accelerated the initiation of Kras G12D-driven lung tumorigenesis, increased tumor burden, …

2023年5月12日 · SETD2是一种RNA聚合酶II（Pol II）相关的 组蛋白甲基转移酶，催化H3K36me2的甲基化，从而在转录活跃区域产生H3K36me3修饰。 SETD2是不同癌症类型中 …

2023年2月22日 · SETD2, a H3K36 trimethyltransferase, is the most frequently mutated epigenetic modifier in lung adenocarcinoma, with a mutation frequency of approximately 9%. However, …

To explore if the synthetic lethal interaction between SETD2 loss and targeted PI3Kβ inhibition specifically affects cell proliferation, we treated SETD2 (+/+) 786-0, SETD2 (KO) 786-0, and …

2022年2月17日 · Since SETD2 is the major trimethylase for H3K36 (Edmunds et al., 2008; Yuan et al., 2009b), we also generated a Setd2 KO by CRISPR to be able to analyze the impact of …

2017年7月27日 · Our study identifies STAT1 methylation on K525 catalyzed by the methyltransferase SETD2 as an essential signaling event for IFNα-dependent antiviral …

2024年10月10日 · As shown by MS, cells lacking functional SETD2 (SETD2-KO) have at least a sixfold-reduction of H3K36me3 in comparison to parental cells (Fig. 2a, Additional file 1: Fig. …