In this study, we investigated the potential regulation of cyclin A-Cdk2 activity by Skp1 and Skp2. We found that Skp2 can inhibit the kinase activity of cyclin A-Cdk2 in vitro, both by direct …

2023年7月3日 · Here we describe the experimentally determined structure of the isolated CDK2-cyclin A-CKS1-p27-SKP1-SKP2 complex at 3.4 Å global resolution using cryogenic electron …

1999年6月25日 · Here we show that the F-box protein SKP2 specifically recognizes p27 in a phosphorylation-dependent manner that is characteristic of an F-box-protein–substrate …

2018年2月14日 · According to this model, cytoplasmic STIL is degraded by SCF-βTrCP throughout interphase, while centrosome-associated STIL is protected, possibly through …

Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to...

2018年2月14日 · SCF-βTrCP-mediated degradation of STIL occurs throughout interphase and mutations in the DSG motif causes massive centrosome amplification, attesting to the …

SCF (Skp1/Cul1/F-box) ubiquitin ligases act as master regulators of cellular homeostasis by targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F-box …

环状RNA(circ-Foxo3)通过与p21(CDK2抑制剂)和 CDK2形成三元复合物, 可延缓细胞增殖, 主要是因 为circ-Foxo3与p21和CDK2的相互作用, 增强了p21 与细胞核中cyclin E/A和CDK2结合, 形 …

These data indicate that Cdk2/cyclin-A-mediated Cdh1 phosphorylation is a critical step for Plk1 to interact with, and phosphorylate Cdh1, which subsequently induces β-TRCP binding to Cdh1 . …

2008年2月2日 · Cyclin-dependent kinase (CDK)2-mediated phosphorylation of Skp2 on Ser64 allows its expression in mid-G1 phase, even in the presence of active APC Cdh1. …