硬脂酰辅酶A去饱和酶1（SCD1）是燃料代谢的中央调节器，可能是控制肥胖和相关代谢性疾病（包括Ⅱ型糖尿病和肝脂肪变性）进展的治疗靶点。 SCD1催化合成 单不饱和脂肪酸 （MUFA），主要是油酸（C18:1）和棕榈油酸（C16:1），这对于控制高碳水化合物饮食的体重增加很重要。 在本文中，我们评估了SCD1亚型在调节代谢组织中脂质和葡萄糖代谢中的作用。 最近研究结果的这些亮点旨在促进我们对SCD1在代谢疾病发展中的作用的理解，这可能有助于评 …

Numerous SCD isoforms exist in mouse and humans, i.e., SCD-1 to SCD-4 and SCD-1 and SCD-5, respectively. Overexpression of SCD is evident and implicated in metabolic diseases such as diabetes and non-alcoholic fatty liver disease. SCD also stimulates canonical Wnt pathway and YAP activation in support of stemness and tumorigenesis.

2024年1月1日 · By regulating downstream signaling pathways such as Wnt/β-catenin, AMPK/mTOR, AKT/FOXO3, ACC/CPT-1 and PI3K/AKT, SCD1 plays a key role in glycolipid metabolism, cellular differentiation, autophagy, inflammation and embryonic development.

2013年9月26日 · In this study, Rios-Esteves and Resh show that stearoyl CoA desaturase (SCD) generates the palmitoleate substrate for the Wnt acyltransferase Porcupine and that Porcupine transfers monounsaturated, but not saturated, fatty acids to Wnt proteins. Their finding that SCD inhibition blocks Wnt3a secretion and renders Wnt inactive suggests that SCD ...

2022年10月6日 · The findings indicate that the RUNX2/SCD1 axis may act as a potential therapeutic target via the Wnt/β-catenin signaling pathway of ccRCC.

硬脂酰辅酶A去饱和酶（stearoyl-CoA desaturase，SCD）是催化饱和脂肪酸向单不饱和脂肪酸转化的关键限速酶。SCD1是SCD的主要亚型，其表达受饱和脂肪酸、多不饱和脂肪酸、单不饱和脂肪酸、胰岛素和瘦素等因素的调节。

2020年1月25日 · SCD produces MUFAs such as palmitoleate (16:1) which is used to lipidate Wnt proteins via Porcupine acyltransferase for their extracellular release. Scd1/2 is a Wnt-target gene and its transcription is amplified by association of β-catenin with SREBP-1 and NF–Y bound to the respective elements in the Scd1/2 proximal promoter.

2017年5月1日 · SCD is a target of the canonical Wnt pathway effector β-catenin. Monounsaturated fatty acids produced by SCD positively feed forward to amplify the Wnt pathway by supporting the expression of the Wnt receptor LRP5/6.

SCD1 plays an important role in cancer, promoting cell proliferation and metastasis. The role of autophagy in cancer is more complex since it can act either by protecting against the onset of cancer or by promoting tumor growth. Mounting evidence indicates that autophagy and lipid metabolism are tightly interconnected.

抑制硬脂酰辅酶a去饱和酶 1 (scd1) 通过调节癌细胞中的 β-连环蛋白信号和 t 细胞中的 er 应激增强抗肿瘤 t 细胞反应，并与抗 pd-1 抗体协同作用。 Journal for ImmunoTherapy of Cancer ( IF 10.3 ) Pub Date : 2022-07-01 , DOI: 10.1136/jitc-2022-004616