Coronavirus biology and replication: implications for SARS-CoV-2 …
2020年10月28日 · Detailed ultrastructural investigation of the SARS-CoV-2 replication structures and assembly process, notably detecting viral (presumably double-stranded) RNA inside DMVs.
SARS-CoV-2 Life Cycle: Stages and Inhibition Targets
Stages of the SARS-CoV-2 Life Cycle: 1. Virus Entry. 2. Translation of Viral Replication Machinery. 3. Replication. 4. Translation of Viral Structure Proteins. 5. Virion Assembly. 6. …
COVID-19: Coronavirus replication, pathogenesis, and therapeutic ...
2020年5月12日 · Overview of COVID-19, SARS-CoV-2 replication, and therapeutic targets. Upper left. Virus entry entails binding the angiotensin-converting enzyme 2 (ACE2) receptor and …
Structures and functions of coronavirus replication–transcription ...
2021年11月25日 · Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses rely on a cohort of specialized viral proteins to transcribe and replicate their …
The Life of SARS-CoV-2 Inside Cells: Replication-Transcription
2022年6月22日 · Nonstructural proteins (also known as replicase proteins) with versatile biological functions play central roles in viral replication and transcription inside the host cells, …
Replication and single-cycle delivery of SARS-CoV-2 replicons
2021年10月14日 · In this work, we use a yeast-based reverse genetics system to develop spike-deleted SARS-CoV-2 self-replicating RNAs. These noninfectious self-replicating RNAs, or …
SARS-CoV-2—Virus structure and life cycle - ScienceDirect
2024年1月1日 · By unraveling the intricate details of its genetic material, protein composition, and replication process, we have gained crucial insights into how SARS-CoV-2 infects and spreads …
Coronavirus biology and replication: implications for SARS-CoV-2
In this Review, we summarize the first discoveries that shape our current understanding of SARS-CoV-2 infection throughout the intracellular viral life cycle and relate that to our knowledge of …
Host cell cycle checkpoint as antiviral target for SARS-CoV-2 …
2023年1月3日 · Both DNA and RNA viruses can modulate cell cycle progression to maximize their replication. 1 However, the effects of SARS-CoV-2 on cell cycle progression remains largely …
In this work, we use a yeast-based reverse genetics system to develop spike-deleted SARS-CoV-2 self-replicating RNAs. These noninfectious self-replicating RNAs, or replicons, can be trans …