2013年2月1日 · Results: Q40P/S47I/H93G could activate all subtypes of FGF receptors in vitro much more strongly than the wild-type without endogenous or exogenous heparin. …

2013年2月1日 · Human fibroblast growth factor-1 (FGF1) has radioprotective effects on the intestine, although its structural instability limits its potential for practical use. Several stable …

2005年9月30日 · The introduction of a double mutation (Q40P/S47I) and a triple substitution (Q40P/S47I/H93G) increased the T den value of FGF-1 to 55.5 °C and 61.8 °C, respectively. …

2019年8月15日 · Using a pull-down technique, we showed the inability to bind integrin α v β 3 for both R35E and its stabilized version (R35E Q40P/S47I/H93G) (Figure 2 B). At the same time, …

2009年9月9日 · Combination of Q40P, S47I, and H93G substitutions dramatically slowed the proteolytic processing extending the protein half-life 15 times in the case of the 3x/K118E …

2007年6月14日 · Crystal structure of highly stable mutant Q40P/S47I/H93G of human fibroblast growth factor-1

Here, we present the structure of the Q40P/S47I/H93G triple mutant of FGF-1 solved by X-ray crystallography to a resolution of 1.70 Å. Recently, we reported that this triple mutant of FGF-1 …

Here, we present the structure of the Q40P/S47I/H93G triple mutant of FGF-1 solved by X-ray crystallography to a resolution of 1.70 A ̊ .

The structure of the Q40P/S47I/H93G triple mutant of FGF-1 is presented, which exhibits much higher stability, a prolonged half-life and enhanced mitogenic activity, and three localized …

Results: Q40P/S47I/H93G could activate all subtypes of FGF receptors in vitro much more strongly than the wild-type without endogenous or exogenous heparin. Preirradiation treatment …