2019年1月24日 · The effect of the sulphur atom on the uracil ring was analyzed in different DNA:RNA microhelixes with three nucleotide base-pairs, including uridine, 2-thiouridine, 4-thiouridine, 2,4-dithiouridine, cytidine, adenosine and guanosine. Distinct backbone and helical parameters were optimized at different density functional (DFT) levels.

The effect of the sulphur atom on the uracil ring was analyzed in different DNA:RNA microhelixes with three nucleotide base-pairs, including uridine, 2-thiouridine, 4-thiouridine, 2,4-dithiouridine, cytidine, adenosine and guanosine. Distinct backbone and …

2002年4月15日 · Based on the structure of the 30S ribosomal subunit 3, protein S4 is ∼ 80 Å from U516, strongly suggesting that the N-terminal domain of RsuA binds to rRNA during ribosome assembly at a ...

2017年6月16日 · UraA consists of 14 transmembrane segments (TMs) that are organized into two distinct domains, the core domain and the gate domain, a structural fold that is also shared by the SLC4 and SLC26...

2025年3月20日 · Four uracil sensors called uracil DNA glycosylases (UDGs), namely UNG (uracil DNA N-glysosylase), SMUG1 (single-strand-selective monofunctional uracil DNA glysosylase 1), TDG, and MBD4, have been characterized in human cells with different cellular localization and catalytic efficiency to ensure efficient uracil recognition and excision. 19,23 ...

2016年8月24日 · In an effort to gain this information in an unbiased fashion, we used a high-throughput phenotypic screen to identify small molecules that disrupted bacterial pathogenesis and increased host survival using the model nematode Caenorhabditis elegans.

2015年2月11日 · Uracil stimulation rapidly induced DUOX activation of these GF animals (Figure S4A), indicating that uracil recognition (presumably by GPCR that acts with Cad99C) acts as a downstream event of Hh signaling.

2019年1月24日 · Abstract The effect of the sulphur atom on the uracil ring was analyzed in different DNA:RNA microhelixes with three nucleotide base-pairs, including uridine, 2-thiouridine, 4-thiouridine, 2,4-dithiouridine, cytidine, adenosine and guanosine. Distinct backbone and helical parameters were optimized at different density functional (DFT) levels.

2024年6月6日 · At a low concentration that did not change the ATRi sensitivity of cells treated with control siRNA, Cy3-dUTP increased the ATRi sensitivity of UNG knockdown cells (Figure S4 D), supporting the notion that dUTP misincorporation increases …

Uracil (/ ˈjʊərəsɪl /) (symbol U or Ura) is one of the four nucleotide bases in the nucleic acid RNA. The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by thymine (T). Uracil is a demethylated form of thymine.