2022年1月1日 · Whereas S1P processes a set of substrates independently of S2P, the latter acts in concert with S1P in a mechanism, called regulated intramembrane proteolysis, that controls lipid metabolism and response to unfolded proteins. This review summarizes the molecular roles that S1P and S2P jointly play in these processes.

在高尔基体，s1p 和 s2p 对 bzip 蛋白的切割都是必不可少的，尽管只能检测到 s2p 的切割产物。 一个可能的原因是，S1P 的切割是必要的第一步，能增强 S2P 的作用，S1P 一旦完成切割，S2P 就立即切割，因此很难检测到仅发生 S1P 切割的中间体。

人类表达两种不同的SREBP，称为固醇调节元件结合转录因子1（SREBF1）和SREBF2。 哺乳动物的SREBF1有两种转录本， SREBP-1a 和 SREBP-1c （也称为adipocyte differentiation-1，ADD1）。

2023年6月3日 · Here, we show that the lipogenesis signal cascade Scap-SREBP1-S1P/S2P orchestrates the homeostasis and spatiotemporal activation of NF-κB. SREBP cleavage-activating protein (Scap) and sterol regulatory element-binding protein 1 (SREBP1) form a super complex with inhibitors of NF-κB α (IκBα) to associate NF-κB close to the endoplasmic ...

Here, we show that ATF6 is processed by Site-1 protease (S1P) and Site-2 protease (S2P), the enzymes that process SREBPs in response to cholesterol deprivation. ATF6 processing was blocked completely in cells lacking S2P and partially in cells lacking S1P.

Here, we review recent research on S2P cascades, including human S2P, E. coli RseP, B. subtilis SpoIVFB and the newly identified S2P homologs. We also discuss the variation and conservation of characterized S2P cascades.

2021年1月15日 · 一旦到了高尔基体，SREBP-2/Scap复合物就会遇到活化的蛋白酶， S1P (site-1 protease)和 S2P。 S1P首先会把SREBP两个跨膜结构域的loop切断，将SREBP分成两个部分，此时每一部分仍然有一个跨膜结构域保留在膜上。 随后S2P会继续在连接SREBP N端结构域的跨膜区切割，于是SREBP的N端转录因子结构域被释放，然后进核启动相关基因的表达 【1-3】 （图1）。 图1. SREBP信号通路简化示意图. 尽管这条信号通路已经发现了几十年，但是具体的结 …

2015年4月28日 · Site-2 protease (S2P) was the first isolated intramembrane-cleaving protease (I-CLiPs), which is a zinc metalloprotease with several putative membrane-associated or -embedded domains, and functions together with another membrane-associated serine protease site-1 protease (S1P). S2P is essential in mammalian cells owing to its regulatory role in ...

2003年8月1日 · Site-1 protease (S1P) and site-2 protease (S2P) reside in the Golgi membranes, where they also process other proteins in addition to SREBP, such as ATF6 (activating...

Whereas S1P processes a set of substrates independently of S2P, the latter acts in concert with S1P in a mechanism, called regulated intramembrane proteolysis, that controls lipid metabolism and response to unfolded proteins. This review summarizes the molecular roles that S1P and S2P jointly play in these processes.