S100 protein expression is seen in cartilaginous tumors, myoepithelial tumors, Schwann cells and neural tumors, Langerhans cell proliferations, benign and malignant melanocytes, clear cell sarcoma, and some carcinomas (particularly of the breast). S100 staining occurs both in the nucleus and cytoplasm.

Immunohistochemistry is an integral component in the proper analysis of soft tissue tumours, and a simple panel of six markers is useful in practical triage: CD34, desmin, epithelial membrane antigen (EMA), keratin cocktail AE1/AE3, S100 protein and alpha smooth muscle actin (SMA).

Clone EP32 was raised against S-100 beta protein. Immunoreactivity was observed in neuroectodermal tissue e.g. melanocytes, nerve fibres, dendritic cells, adipocytes and a percentage of macrophages, lymphocytes and plasma cells.

How do pathologists test for S100? Pathologists use immunohistochemistry (IHC) to look for S100 in tissue samples. In this test, a small piece of tissue is treated with special antibodies that bind to the S100 protein.

S100 is an antibody marker that reacts with antigens present in conditions like melanoma. S100 is normally present in cells derived from the neural crest like Schwann cells, and melanocytes, chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes.

The purpose of this research is to evaluate the biological behavior and histological subtypes of head and neck BCC by analyzing the expression of biomarkers such as alpha-smooth muscle actin (α-SMA), podoplanin, S100, MMP-13, and HER2neu using immunohistochemistry.

S-100 protein is a highly sensitive marker for melanomas but lacks specificity. It is positive (both nuclear and cytoplasmic staining) in 94-100% of primary and metastatic tumors.

S100 is a 21kDa highly acidic and water soluble protein first isolated from brain but later shown to be produced by a wide variety of normal and neoplastic cells of mesodermal, neuroectodermal, and epithelial origin. S-100 protein may be found in the cell membranes, cytoplasm and nuclei.

In this review, we outline the potential role of the S100 protein members in pulmonary diseases and detail potential molecular mechanisms they may play in disease initiation and progression. Equally, we outline potential therapeutic approaches to treat pulmonary diseases by targeting S100 proteins. 2.

2021年2月11日 · S-100 staining in a secretory carcinoma of the salivary gland. S-100, also S100, is a commonly used immunostain. It marks nerves. Nerves. Schwannoma. Mature adipose tissue. Interdigitating dendritic cells. [1] Langerhans cell histiocytosis. Rosai-Dorfman disease. Chordoma - also keratin positive (AE1/AE3, CK19, CAM5.2). [2] Granular cell tumour.