2025年3月30日 · RPL5 (Ribosomal Protein L5) is a Protein Coding gene. Diseases associated with RPL5 include Diamond-Blackfan Anemia 6 and Diamond-Blackfan Anemia. Among its related pathways are Peptide chain elongation and Nervous system development. Gene Ontology (GO) annotations related to this gene include RNA binding and structural constituent of ribosome.

编码的蛋白质结合 5S rRNA 形成称为 5S 核糖核蛋白颗粒 (RNP) 的稳定复合物，这是将非核糖体相关的细胞质 5S rRNA 运输到核仁以组装成核糖体所必需的。 编码的蛋白质还可以通过激活下游肿瘤抑制因子和下调癌蛋白表达来抑制肿瘤发生。 已在 Diamond-Blackfan 贫血 (DBA) 患者中发现该基因的突变。 该基因与位于其第五个内含子的小核仁 RNA 基因 U21 共同转录。 对于编码核糖体蛋白的基因来说，这是典型的，该基因有多个经过处理的假基因分散在整个基因组中。 …

60S ribosomal protein L5 is a protein that in humans is encoded by the RPL5 gene. [5][6] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and …

Ribosomal protein L5 (RPL5)/ E2F transcription factor 1 (E2F1) signaling suppresses breast cancer progression via regulating endoplasmic reticulum stress and autophagy. Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly.

2025年2月9日 · Ribosomal protein L5 (RPL5)/ E2F transcription factor 1 (E2F1) signaling suppresses breast cancer progression via regulating endoplasmic reticulum stress and autophagy.

2025年2月9日 · Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway. Zhang H, Liu J, Dang Q, Wang X, Chen J, Lin X, Yang N, Du J, Shi H, Liu Y, Han JZhang H, et al. BMC Mol Cell Biol, 2022 Nov 16. PMID 36384455. Cytosolic import factor- and Ran-independent nuclear transport of ribosomal protein L5.

2017年2月28日 · RPL5 was located at a significant peak of heterozygous deletion or mutated in 11% of glioblastoma, 28% of melanoma and 34% of breast cancer samples. Moreover, patients with low RPL5 expression displayed worse overall survival in …

The RPL5 gene provides instructions for making one of approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. Learn about this gene and related health conditions.

Perturbations in ribosome biogenesis have been associated with cancer. Such aberrations activate p53 through the RPL5/RPL11/5S rRNA complex-mediated inhibition of HDM2. Studies using animal models have suggested that this signaling pathway might constitute an important anticancer barrier.

Ribosomal protein L5 (RpL5) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL5 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles.