经典且复杂的细胞信号通路：RAS/RAF/MEK/ERK - 知乎
RAS蛋白家族包括四种：KRAS (两种剪切体4a和4b)、HRAS、NRAS；四种蛋白序列相似度很高，在细胞膜内的定位略有差异，但都和癌症发生相关。 其中KRAS激活突变突变最常见，其突 …
The Interplay between ROS and Ras GTPases: Physiological and ...
Although several studies implicate RasGTPases in the production and regulation of intracellular ROS, many evidences indicate that Ras proteins can also be direct targets of ROS. Similar to …
ROS, autophagy, mitochondria and cancer: Ras, the hidden master?
2013年5月1日 · In this review we make an attempt to summarize and illustrate the recent experimental evidence indicating the interplay between an altered redox status and cellular bio …
Ras, ROS and Proteotoxic Stress: A Delicate Balance
2011年9月13日 · Ras-deregulated cells require reactive oxygen species for proliferation. They survive the resultant proteotoxic stress by maintaining sufficient levels of reduced glutathione …
【科普】关于Ras通路 - 知乎 - 知乎专栏
当gef帮助将gdp换成gtp之后，ras是“活了”的状态；之后， gap 可以将gtp水解变成gdp，使得ras回到死了的状态。 RAS的活跃可以促进下游通路，进而导致细胞的增殖。
Stimulation of RAS-dependent ROS signaling extends longevity …
2022年11月30日 · We show that elevation of mitochondrial superoxide generation increases Caenorhabditis elegans life span by enhancing a RAS-dependent ROS (reactive oxygen …
Unraveling the interplay between RAS/RAF/MEK/ERK signaling …
2023年11月1日 · Additionally, oxidative stress can activate the RAS/RAF/MEK/ERK signaling pathway, where reactive oxygen species (ROS) interact with receptor tyrosine kinases (e.g., …
The impact of oncogenic RAS on redox balance and implications …
2019年12月18日 · Cyclooxygenase-2 supports mutant RAS-induced ROS generation. Oncogenic RAS reprograms metabolism to favor glutathione biosynthesis and increase NADPH/NADP + …
Ras-induced ROS upregulation affecting cell proliferation is …
One of mechanisms by which Ras proteins influence cell growth is a regulation of intracellular level of reactive oxygen species (ROS), second messengers affecting variety of cellular …
Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS ...
2021年8月15日 · Oncogenic RAS aberrantly rewires metabolic pathways promoting the generation of intracellular reactive oxygen species (ROS). In particular, lipids have gained …