2024年11月1日 · ROS contribute to GLUT4 translocation that increases skeletal muscle glucose uptake during exercise and stimulate signalling pathways that increase GLUT4 expression. Conversely, ROS can also inhibit GLUT4 translocation …

2019年10月11日 · In skeletal muscle fibers, ROS have been suggested to stimulate glucose transporter 4 (GLUT4)-dependent glucose transport during artificially evoked contraction ex vivo, but whether myocellular...

Piperine in pepper prevents hyperglycemia by GLUT4 translocation through CaMKKβ/AMPK signaling via TRPV1-dependent increase in the intracellular Ca 2+ level and ROS generation.

Mitochondrial reactive oxygen species (ROS) production and detoxification are tightly balanced. Shifting this balance enables ROS to activate intracellular signaling and/or induce cellular damage and cell death. Increased mitochondrial ROS production is observed in a number of pathological conditions characterized by mitochondrial dysfunction.

GLUT4 mediates the effects of insulin, or insulin-like growth factor on regulations of cognition, memory, behavior, motor activity and seizures. GLUT4 positive neurons are responsible for glucose sensing. Physical activity improves GLUT4 translocation in neurons, a process that needs Rab10 phosphorylation.

ros 有助于 glut4 易位，从而增加运动期间骨骼肌葡萄糖的摄取，并刺激增加 glut4 表达的信号通路。 相反，ROS 还可以抑制代谢疾病状态下的 GLUT4 易位和表达。

2024年11月1日 · ROS contribute to GLUT4 translocation that increases skeletal muscle glucose uptake during exercise and stimulate signalling pathways that increase GLUT4 expression. Conversely, ROS can also inhibit GLUT4 translocation …

2016年9月16日 · In the present study, we found that chronic H 2 O 2 exposure inhibited insulin-stimulated Akt2 phosphorylation, GLUT4 translocation and glucose uptake in C2C12 myotubes, which also gave an exact evidence for ROS-induced insulin resistance in muscles.

2018年5月1日 · 在骨骼肌中，ROS 与孤立的电刺激肌肉中的葡萄糖转运有关，但在体内运动中 ROS 的确切来源以及它是否控制葡萄糖转运蛋白 4 (GLUT4) 对体内葡萄糖的摄取尚不清楚。 在这里，我们利用遗传编码的生物传感器、荧光染料和缺乏 NADPH 氧化酶 2 (NOX2) 调节亚基 p47phox 和 Rac1 的小鼠模型的组合来证明 NOX2 是骨骼肌体内跑步机运动过程中 ROS 的主要来源。 此外，p47phox 缺陷小鼠表型复制 Rac1 mKO 小鼠代谢失调的关键方面，包括体内葡萄 …

2023年11月11日 · 通过代表生理峰值和 hrt 浓度（0、500 和 2000 pm）的体外孵育，根据子队列中雌激素浓度的增加，评估单核细胞类型的 ros 和 glut4 表达。 结果 健康志愿者的平均年龄为 31.2 岁。