2025年3月30日 · RND3 (Rho Family GTPase 3) is a Protein Coding gene. Diseases associated with RND3 include Cepacia Syndrome and Hydrocephalus. Among its related pathways are GPCR Pathway and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RND2.

Rnd3 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. [5] It is encoded by the gene RND3. [6] Like other members of the Rho family of Ras-related GTPases it regulates the organization of the actin cytoskeleton in response to extracellular growth factors.

该基因编码的蛋白质是小 GTPase 蛋白质超家族的成员。 编码的蛋白质仅结合 GTP 但没有 GTP 酶活性，并且似乎充当细胞骨架组织的负调节剂，导致粘附力丧失。 已经鉴定出编码相同蛋白质的多个可变剪接变体。 [RefSeq 提供，2011 年 12 月] This gene encodes a protein which is a member of the small GTPase protein superfamily.

2016年4月5日 · Microvascular leakage of plasma proteins is a hallmark of inflammation that leads to tissue dysfunction. There are no current therapeutic strategies to reduce microvascular permeability. The purpose of this study was to identify the role of Rnd3, an atypical Rho family GTP ase, in the control of endothelial barrier integrity. The potential ...

2015年12月15日 · The basic role of Rnd3 is to report as an endogenous antagonist of RhoA signaling-mediated actin cytoskeleton dynamics, which specifically contributes to cell migration and neuron polarity. In addition, Rnd3 also plays a critical role in arresting cell cycle distribution, inhibiting cell growth, and inducing apoptosis and differentiation.

2025年2月8日 · Rnd3 Is a Crucial Mediator of the Invasive Phenotype of Glioblastoma Cells Downstream of Receptor Tyrosine Kinase Signalling. RND3 Transcriptionally Regulated by FOXM1 Inhibits the Migration and Inflammation of Synovial Fibroblasts in Rheumatoid Arthritis Through the Rho/ROCK Pathway.

2025年1月10日，空军军医大学西京医院孙冬冬教授团队在国际糖尿病领域经典期刊Diabetes (中科院一区Top期刊)发表了题为“Rnd3 Ameliorates Diabetic Cardiac Microvascular Injury via Facilitating Trim40-mediated Rock1 Ubiquitination”的原创研究，揭示了Rnd3在糖尿病心肌微血管 …

In this study, we have identified RND3, a small GTP-binding protein, as a new element in the complex signaling process that leads to macrophage activation. We show that RND3 expression is transiently induced in macrophages activated through Toll receptors and potentiated by IFN- γ.

2025年4月1日 · Rnd3 overexpression mitigates diabetic myocardial microvascular injury and improves cardiac function through the Rock1/myosin light chain signaling pathway. Rnd3 facilitates the recruitment and interaction with Trim40 to promote Rock1 ubiquitination, thereby preserving endothelial barrier integrity in the diabetic heart.

2025年1月5日 · Rnd3 enhances cardiac resilience against DIC by stabilizing mitochondrial dynamics and reducing PANoptosis. Our findings suggest that the Rnd3/Rock1/Drp1 signaling pathway represents a novel target for mitigating DIC, and modulating Rnd3 expression could be a strategic approach to safeguarding cardiac function in patients undergoing Dox treatment.